研究者データベース - 桑原　淳

クワハラ　ジュン KUWAHARA Jun
桑原　淳

所属同志社女子大学薬学部医療薬学科

同志社女子大学大学院薬学研究科医療薬学専攻博士課程

職種特別任用教授

著書・論文歴
著書	医学大辞典（第2版） (共著) 2009/02
論文	Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy Protein Science Vol.26 (No.11),2280-2290頁 (共著) 2017/09/27
論文	Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4 Protein Science Vol.25 (11),2006-2017頁 (共著) 2016/08/24
論文	Interaction between isolated transcriptional activation domains of Sp1 revealed by heteronuclear magnetic resonance. Protein Science Vol.21 (No.10),1481-1488頁 (共著) 2012/10
論文	Interaction of Sp1 zinc finger with transport factor in the nuclear localization of transcription factor Sp1 Biochemical and Biophysical Research Communications Vol.403 (No.2),161-166頁 (共著) 2010/10
論文	Role of zinc finger structure in nuclear localization of transcription factor Sp1 Biochemical and Biophysical Research Communications Vol.380 (Issue.1),28-32頁 (共著) 2009/02
論文	Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement Glycobiology Vol.16 (No.4),271-280頁 (共著) 2006/04
論文	Elastogenesis in cultured dermal fibroblasts from patients with lysosomal β-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies The Journal of Medical Investigation Vol.53 (No.1-2),103-112頁 (共著) 2006/02
論文	Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates Journal of Neurochemistry Vol.92,497-507頁 (共著) 2005/01
論文	Expression of lysosomal protective protein/　cathepsin a in a stably transformed human neuroblastoma cell line during bi-directional differentiation into neuronal and schwannian cells Neurochemistry International Vol.44,447-457頁 (共著) 2004/03
論文	Microbial serine carboxypeptidase inhibitors: comparative analysis of actions on homologous enzymes derived from man, yeast and wheat Journal of Antibiotics Vol.57,316-325頁 (共著) 2004/01
論文	Alpha-helix substitution: novel approach for the design of a new zinc finger peptides for AT-rich sequence Nucleic Acids Research Supplemental Vol.2,67-68頁 (共著) 2002/11
論文	Apoptosis- inducing　activity of synthetic intermediates of halichlorine Bioorganic and Medicinal Chemistry Letters Vol.12,2069-2072頁 (共著) 2002/08
論文	Novel strategy for the design of a new zinc finger: creation of a zinc finger for the AT-rich sequence by alpha-helix substitution Journal of the American Chemical Society Vol.124,6526-6527頁 (共著) 2002/06
論文	Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines Oncogene Vol.20,4718-4727頁 (共著) 2001/08
論文	Zn finger and nuclear localization of transcription factor Sp1 Nucleic Acids Research Symposium Series Vol.44,265-266頁 (共著) 2000/11
論文	Nuclear localization of transcription factor Sp1 Nucleic Acids Research Symposium Series Vol.42,293-294頁 (共著) 1999/11
論文	Gene of rat Ca2+/calmodulin- dependent protein kinase II alpha isoform - its cloning and whole structure Federation of European Biochemical Societies Letters Vol.396,333-336頁 (共著) 1996/11
論文	A novel zinc finger-based DNA cutter : biosynthetic design and sequence-specific DNA cleavage Journal of the American Chemical Society Vol.116,4085-4086頁 (共著) 1994/05
論文	Alteration of DNA binding specificity by nickel (II) substitution in three zinc (Ⅱ) fingers of transcription factor Spl Biochemical and Biophysical Research Communications Vol.194,1515-1520頁 (共著) 1993/08
論文	Cleavage of yeast tRNAPhe with Ni(III) and Co(III) complexes of bleomycin Biochemical and Biophysical Research Communications Vol.191,1338-1346頁 (共著) 1993/08
論文	Binding of transcription factor Spl to GC box DNA revealed by footprinting analysis : different contact of three zinc fingers and sequence recognition mode Biochemisry Vol.32,5994-6001頁 (共著) 1993/06
論文	Guanine-specific binding by bleomycin- nickel (III): complex and its reactivity for guanine-quartet telomeric DNA Biochemistry Vol.32,6141-6145頁 (共著) 1993/06
論文	DNA binding and cleavage of a novel antitumor antibiotic dynemicin A: detection of binding and cleavage sites by exonuclease III digestion and alkali-induced cutting reactions Biochemical and Biophysical Research Communications Vol.190,362-370頁 (共著) 1993/01
論文	Recognition and structural pertubation of GC box DNA by Sp1 zinc finger Nucleic Acids Research Symposium Series Vol.27,175-176頁 (共著) 1992/11
論文	Binding of tachyplesin I to DNA revealed by footprinting analysis : significant contribution of secondary structure to DNA binding and implication for biological action Biochemistry Vol.31,2998-3004頁 (共著) 1992/03
論文	Metal binding and DNA recognition in transcription factor Sp1 Nucleic Acids Research Symposium Series Vol.25,121-122頁 (共著) 1991/10
論文	Role of the zinc (II) ions in the structure of the three-finger DNA binding domain of the Sp1 transcription factor Biochemistry Vol.29,8627-8631頁 (共著) 1990/09
論文	Light-induced DNA cleavage by esperamicin and neocarzinostatin Biochemical and Biophysical Research Communications Vol.164,903-911頁 (共著) 1989/10
論文	Nucleotide- specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics Proceedings of the National Academy of Sciences of the United States of America Vol.86,7672-7676頁 (共著) 1989/10
論文	DNAを標的とする制ガン性薬物による特異的な塩基認識と切断の分子機構に関する研究博士学位論文 (単著) 1988/09
論文	Significant interaction between Low-spin iron (III) site and pyrroloquinoline quinone in active center of nitrile hydratase Biochemical and Biophysical Research Communications Vol.154,522-528頁 (共著) 1988/07
論文	Sequence-specific recognition and cleavage of DNA by metallobleomycin: minor groove binding and possible interaction mode Proceedings of the National Academy of Sciences　of Sciences of the United States of Americapp. Vol.85,2459-2463頁 (共著) 1988/04
論文	Man-designed bleomycin. iron complexation and nucleotide sequence cleavage by synthetic models of bleomycin International Journal of Experimental and Clinical Chemotherapy Vol.1,12-22頁 (共著) 1988/01
論文	A new antitumor complex : bis(acetate) bis(imidazole) copper (II) Journal of the American Chemical Society Vol.109,6870-6871頁 (共著) 1987/10
論文	Nitrile hydratase: the first non-heme iron enzyme with A typical low-spin Fe (III) -active center Journal of the American Chemical Society Vol. 109,5848-5850頁 (共著) 1987/09
論文	New lumibleomycin- containing thiazolylisothiazole ring Journal of the American Chemical Society Vol.109,938-939頁 (共著) 1987/02
論文	Phototransformed bleomycin antibiotics : structure and DNA cleavage activity Journal of the American Chemical Society Vol.108,7089-7094頁 (共著) 1986/10
論文	Photosensitive DNA cleavage and phage inactivation by copper (II)- camptothecin Biochemistry Vol.25,1216-1221頁 (共著) 1986/05
論文	Copper bleomycin has no significant DNA cleavage activity Biochemistry Vol.24,4719-4721頁 (共著) 1985/08
論文	Effective DNA cleavage by bleomycin- vanadium (IV) complex plus hydrogen peroxide Biochemical and Biophysical Research Communications Vol.129,368-374頁 (共著) 1985/06
論文	Nucleotide sequence cleavages of manganese- bleomycin induced by reductant, hydrogen peroxide and ultraviolet light. Comparison with iron-and cobalt-bleomycins Biochimica et Biophysica Acta Vol.824,330-335頁 (共著) 1985/04
論文	Nature of carbon monoxide binding of iron (II)- bleomycin Federation of European Biochemical Societies Letters Vol.182,39-42頁 (共著) 1985/03
論文	Synthetic studies towards man designed bleomycins . synthesis of a DNA cleaving molecule based on bleomycin Tetrahedron Letters Vol.27,3639-3642頁 (共著) 1985/03
論文	DNA interaction and nucleotide sequence cleavage of copper- streptonigrin Biochimica et Biophysica Acta Vol.782,254-261頁 (共著) 1984/07
論文	Nucleotide sequence cleavage of guanine-modified DNA with aflatoxin B1, dimethyl sulfate, and mitomycin C by bleomycin and deoxyribonuclease I Biochemical and Biophysical Research Communications Vol.117,916-922頁 (共著) 1983/12
論文	Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis- diamminedichloroplatinum (II) Proceedings of the National Academy of Sciences of the United States of America Vol.80,6795-6798頁 (共著) 1983/11
論文	ESR characteristics of sulfhydryl- containing peptide-nickel (III) complexes: implication for nickel (III) center of hydrogenases Biochemical and Biophysical Research Communications Vol.115,878-881頁 (共著) 1983/09
論文	Uncommon axial selenium-ligation in iron-bleomycin and hemoglobin Journal of the Chemical Society Chemical Communications Vol.16,908-909頁 (共著) 1982/08
論文	0n the mechanism of hydrogen peroxide-, superoxide-, and ultravio1et light- induced DNA cleavages of inactive b1eomycin-iron (III) complex Biochemical and Biophysical Research Communications Vol.105,1511-1518頁 (共著) 1982/04
その他	Dual role of zinc finger in nuclear import of transcription factor Sp1 14th International Conference on Biological Inorganic Chemistry（ICBIC 14）　名古屋国際会議場 2009/07
その他	Znフィンガー型DNA切断分子の分子設計タンパク質核酸酵素 40巻,1457-1464頁 (共著) 1995/07
その他	転写因子Sp1からZnフィンガーヌクレアーゼの分子設計へ生物物理 34巻 1994/12
その他	Znフィンガー：金属イオンがかかわる新しいDNA認識モチーフ化学 48巻,121-125頁 (共著) 1992/02