研究者データベース - 藤井　健志

フジイ　タケシ FUJII Takeshi
藤井　健志

所属同志社女子大学薬学部医療薬学科

職種教授

著書・論文歴
著書	Advances in Neuroregulation and Neuroprotection,737-750頁 (共著) 2005/02
著書	Kinases and phosphatases in lymphocyte and neuronal signalin,357-358頁 (共著) 1997/11
著書	Neurochemistry,813-819頁 (共著) 1997/11
著書	The Hippocampus: functions and clinical relevance,491-494頁 (共著) 1996/06
論文	ポリADP-リボシル化修飾反応に関わるタンパク質の細胞周期過程における発現および細胞内局在パターンの解析同志社女子大学学術研究年報第72巻 (共著) 2022/01
論文	マウス腹腔内マクロファージにおけるアセチルコリン受容体の生理的役割の解明同志社女子大学学術研究年報第71巻 (共著) 2021/01
論文	ヒトマクロファージ様細胞株U937細胞におけるアセチルコリン受容体の生理的役割の検討同志社女子大学　学術研究年報第70巻,13-19頁 (共著) 2019/12/24
論文	T細胞活性化によるアセチルコリン受容体の発現抑制機構の検討同志社女子大学　学術研究年報第69巻,63-72頁 (共著) 2018/12/26
論文	ナマコ由来成分IJ-337のT細胞の機能とコリン作動系活性に及ぼす影響同志社女子大学学術研究年報第68巻,59-66頁 (共著) 2017/12/26
論文	Mechanisms of chronic nicotinic treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons（査読付） Journal of Pharmacological Sciences Vol.112,265-272頁 (共著) 2010/05
論文	Acetylcholine synthesis and release in NIH3T3 cells co-expressing the high-affinity choline transporter and choline acetyltransferase（査読付） Journal of Neuroscience Research Vol.87,3024-3032頁 (共著) 2009/10
論文	Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation（査読付） Biological Pharmaceutical Bulletin Vol.32,318-324頁 (共著) 2009/05
論文	Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil（査読付） Journal of Neuroscience Reseach Vol.86,3575-83頁 (共著) 2008/12
論文	Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment（査読付） European Journal of Pharmacology Vol.590,150-156頁 (共著) 2008/08
論文	Basic and clinical aspects of non-neuronal acetylcholine: Expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy（査読付） Journal of Pharmacological Sciences Vol.106,186-192頁 (共著) 2008/02
論文	Basic and clinical aspects of non-neuronal acetylcholine: Introduction: Non-neuronal cholinergic system and its biological significance（査読付） Journal of Pharmacological Sciences Vol.106,167-173頁 (共著) 2008/02
論文	Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice（査読付） Journal of Neuroimmunology Vol.188,80-85頁 (共著) 2007/08
論文	Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity（査読付） Life Sciences Vol.80,2320-2324頁 (共著) 2007/03
論文	Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems（査読付） Life Sciences Vol.80,2206-2209頁 (共著) 2007/03
論文	Neuroprotective effects of galanthamine and tacrine against glutamate neurotxicity（査読付） European Journal of Pharmacology Vol.549,19-26頁 (共著) 2006/11
論文	Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways（査読付） Journal of Neuroimmunology Vol.179,101-107頁 (共著) 2006/10
論文	Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea（査読付） Life Sciences Vol.77,1935-1944頁 (共著) 2005/07
論文	Novel analogs of choline as potential neuroprotective agents（査読付） Journal of Alzheimers Disease Vol.6(6 Suppl),S85-92頁 (共著) 2004/12
論文	Expression of neon-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function Frontiers in Bioscience Vol.9,2063-2085頁 (共著) 2004/09
論文	Up-regulation of lymphocytic cholinergic activity byONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells（査読付） Vascular Pharmacology Vol.41,51-58頁 (共著) 2004/03
論文	The lymphocytic cholinergic system and its contribution to the regulation of immune activity（査読付） Life Sciences Vol.74,675-696頁 (共著) 2003/12
論文	The endogenous, immunologically active peptide apelin inhibits lymphocytic cholinergic activity（査読付） Journal of Neuroimmunology Vol.144,46-52頁 (共著) 2003/11
論文	Expression of acetylcholine in lymphocytes and modulation of an independent lymphocytic cholinergic activity by immunological stimulation（査読付） Biogenic Amines Vol.17,373-386頁 (共著) 2003/04
論文	Up-regulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses（査読付） Neurochemical Research Vol.28,423-429頁 (共著) 2003/04
論文	Acetylcholine increase in amniotic fluid of experimental rats for intrauterine growth retardation（査読付） Life Sciences Vol.72,2145-2150頁 (共著) 2003/03
論文	Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line（査読付） Life Sciences Vol.72,2131-2134頁 (共著) 2003/03
論文	Expression of multiple species for choline acetyltransferase mRNA in human T-lymphocytes（査読付） Life Sciences Vol.72,2127-2130頁 (共著) 2003/03
論文	Induction of nitric oxide (NO) synthase expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM human leukemic T-cell line（査読付） Life Sciences Vol.72,2151-2154頁 (共著) 2003/03
論文	Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit gene expression in the CEM human leukemic T-cell line（査読付） Life Sciences Vol.72,2155-2158頁 (共著) 2003/03
論文	The lymphocytic cholinergic system and its biological roles（査読付） Life Sciences Vol.72,2101-2110頁 (共著) 2003/03
論文	Evolutional study on acetylcholine expression（査読付） Life Sciences Vol.72,1745-1756頁 (共著) 2003/02
論文	Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line（査読付） Journal of Neuroimmunology Vol.128,1-8頁 (共著) 2002/07
論文	Decreased acetylcholine content and choline acetyltransferase mRNA expression in circulating mononuclear leukocytes and lymphoid organs of the spontaneously hypertensive rat（査読付） Life Sciences Vol.69,1629-1638頁 (共著) 2001/08
論文	YM905, a novel M3 antagonist, inhibits Ca2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T-cells（査読付） General Pharmacology Vol.35,71-75頁 (共著) 2001/08
論文	The non-neuronal cholinergic system: an independent non-neuronal cholinergic system in lymphocytes（査読付） Japanese Journal of Pharmacology Vol.85,11-15頁 (共著) 2001/01
論文	The non-neuronal cholinergic system: non-neuronal neurotransmitters and neurotrophic factors in amniotic epithelial cells: expression and function in humans and monkey（査読付） Japanese Journal of Pharmacology Vol.85,20-23頁 (共著) 2001/01
論文	Calcium signaling and c-fos gene expression via M3 muscarinic acetylcholine receptors in human T-and B-cells（査読付） Japanese Journal of Pharmacology Vol.84,124-132頁 (共著) 2000/10
論文	Effects of physostigmine and calcium on acetylcholine efflux from the hippocampus of freely moving rats as determined by in vivo microdialysis and radioimmunoassay（査読付） Neuroscience Letters Vol.289,181-184頁 (共著) 2000/08
論文	Ca2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor in human T- and B-cell lines（査読付） Naunyn- Schmiedeberg's Archives of Pharmacology Vol.362,14-21頁 (共著) 2000/07
論文	Enhancement of hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by repeated lithium treatment in rats（査読付） Canadian Journal of Physiology and Pharmacology Vol.78,392-399頁 (共著) 2000/05
論文	Enhancement of cerebral cortical acetylcholine release by intraperitoneal acetic acid and its suppression by analgesics in freely moving rats（査読付） Neuroscience Letters Vol.284,163-166頁 (共著) 2000/04
論文	Extraneuronal cholinergic system in lymphocytes（査読付） Pharmacology and Therapeutics Vol.86,29-48頁 (共著) 2000/04
論文	Enhancement of the serotonin- mediated acetylcholine release by repeated desmethyl- imipramine treatment in the hippocampus of freely moving rats（査読付） Japanese Journal of Pharmacology Vol.80,303-309頁 (共著) 1999/08
論文	Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells（査読付） Journal of Neuroscience Research Vol.57,381-387頁 (共著) 1999/08
論文	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines（査読付） Neuroscience Letters Vol.266,17-20頁 (共著) 1999/04
論文	Enhancement of cortical and hippocampal cholinergic neurotransmission release through 5-HT1A receptor mediated pathways by BAYx3702 in freely moving rats（査読付） Neuroscience Letters Vol.265,33-36頁 (共著) 1999/04
論文	Possible dynamic neurotransmitter metabolisms surrounding the fetus（査読付） Journal of Child Neurology Vol.14,265-266頁 (共著) 1999/04
論文	Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine- synthesizing enzyme, in human leukemic T-cell lines（査読付） Neuroscience Letters Vol.259,71-74頁 (共著) 1999/01
論文	Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenyl- alanine-treated rats as measured by in vivo microdialysis（査読付） Neuroscience Research Vol.31,23-29頁 (共著) 1998/05
論文	Acetylcholine synthesis and muscarinic receptor subtypes mRNA expression in T-lymphocytes（査読付） Life Sciences Vol.62,1701-1705頁 (共著) 1998/03
論文	Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phyto- hemagglutinin, a T-cell activator（査読付） Journal of Neuroimmunology Vol.82,101-107頁 (共著) 1998/02
論文	Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis（査読付） Brain Research Vol.761,244-249頁 (共著) 1997/07
論文	Nitric oxide increases stimulation-evoked acetylcholine release from rat hippocampal slices by a cyclic GMP-independent mechanism（査読付） Brain Research Vol.760,158-162頁 (共著) 1997/06
論文	Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees（査読付） Neuroscience Letters Vol.227,21-24頁 (共著) 1997/05
論文	Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholine- sterase inhibitory and acetylcholine release enhancing activities, cause a dose-dependent increase in the blood acetylcholine content of Beagle dogs（査読付） Neuroscience Letters Vol.225,25-28頁 (共著) 1997/03
論文	Antihypertensive effect of repeatedly administered YM358, an angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats（査読付） Japanese Journal of Pharmacology Vol.73,83-91頁 (共著) 1997/01
論文	Phorbol ester enhances choline uptake in cultured porcine brain endothelial cells（査読付） Biogenic Amine Vol.12,49-54頁 (共著) 1996/08
論文	Localization and synthesis of acetylcholine in human leukemic T cell lines（査読付） Journal of Neuroscience Research Vol.44,66-72頁 (共著) 1996/04
論文	Effect of repeated administration of KT3-671, a nonpeptide AT1 receptor antagonist, on diurnal variation in blood pressure, heart rate and locomotor activity in stroke-prone spontaneously hypertensive rats as determined by radio-telemetry（査読付） Journal of Cardiovascular Pharmacology Vol.27,411-416頁 (共著) 1996/03
論文	Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma（査読付） Neuroscience Letters Vol.201,207-210頁 (共著) 1995/12
論文	Antihypertensive effect of chronic KT3-671, a structurally new nonpeptide AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats（査読付） Japanese Journal of Pharmacology Vol.69,215-222頁 (共著) 1995/11
論文	Expression of choline acetyltransferase mRNA and protein in T-lymphocytes（査読付） Proceedings of the Japan Academy Vol.71B,231-235頁 (共著) 1995/08
論文	Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis Brain Research Vol.761,244-249頁 (共著) 1995/07
論文	Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats（査読付） Naunyn-Schmiedeberg's Archives of Pharmacology Vol.350,523-528頁 (共著) 1994/11
論文	脳機能改善薬の海馬における神経化学的作用機序に関する研究（査読付）博士学位論文 (単著) 1993/03
論文	Bifemelane enhances high K+-evoked release of glutamate from mossy fiber synaptosomes of guinea-pig hippocampus（査読付） European Journal of Pharmacology Vol.219,271-277頁 (共著) 1992/03
論文	Specific binding sites for bifemelane in the hippocampus of the guinea pig, relevant to its pharmacological actions（査読付） Neuropharmacology Vol.30,1291-1295頁 (共著) 1991/04
論文	Bifemelane induces translocation of protein kinase C in the CA3, but not CA1, region of guinea-pig hippocampus（査読付） Canadian Journal of Physiology and Pharmacology Vol.68,413-418頁 (共著) 1990/06
その他	リンパ球における非神経性コリン作動系の血液・血管機能に及ぼす影響の解析医科学応用研究振興財団研究報告 Vol.26,332-337頁 (単著) 2007/02
その他	スタチン系高脂血症治療薬の免疫抑制作用とTリンパ球におけるコリン作動系活性との関連の検討三共生命科学研究振興財団研究報告集 Vol.21,129-137頁 (単著) 2005/10
その他	リンパ球に発現するニコチン受容体の機能-喫煙によるα７型ニコチン受容体機能の変化医学のあゆみ 210巻,661-664頁 (共著) 2004/07
その他	リンパ球における非神経性コリン作動系の発見とその生理的役割の解明（査読付）日本薬理学雑誌 123巻,179-188頁 (単著) 2004/01
その他	研究と新薬開発ターゲットとしてのリンパ系コリン作動系ファルマシア 35巻,1031-1035頁 (共著) 1999/10
その他	アセチルコリンのニコチン及びムスカリン受容体薬局 50巻,1315-1323頁 (共著) 1999/05
その他	アセチルコリン受容体薬局 48巻,23-30頁 (共著) 1997/01