研究者データベース - 松野　浩之

マツノ　ヒロユキ MATSUNO Hiroyuki
松野　浩之

所属同志社女子大学薬学部医療薬学科

職種教授

著書・論文歴
著書	シンプル薬理学 (共著) 2008/11
著書	基礎薬理学 (共著) 2008
著書	シンプル薬理学,150-156頁 (共著) 2006
著書	シンプル薬理学,154-161頁 (共著) 2004
著書	血管内皮細胞研究フロンテア,34-44頁 (共著) 2004
論文	Lack of plasminogen activator inhibitor-1 enhances the preventive effect of DX-9065a, a selective factor Xa inhibitor, on venous thrombus and acute pulmonary embolism in mice. Pathophysiol Haemost Thromb 33 (4),206-213頁 (共著)
論文	A synthetic peptide derived from staphylokinase enhances plasminogen activation by tissue-type plasminogen activator J Thromb Haemost. 9巻 (5号),997-1006頁 (共著) 2011/05
論文	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. J Biol Chem. 286巻 (11号),8952-8960頁 (共著) 2011/05
論文	The absence of urokinase-type plasminogen activator receptor plays a role in the insulin-independent glucose metabolism J Cardiovasc Pharmacol 57巻 (3号),334-339頁 (共著) 2011/03
論文	Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway PLoS One 6巻 (1号),16269-16275頁 (共著) 2011/01
論文	Urokinase-type plasminogen activator receptor is associated with the development of adipose tissue Thromb Haemost 104巻 (6号),1124-1132頁 (共著) 2010/09
論文	メタボッリクシンドロームにおける脂肪細胞の機能解明と新たな治療ストラテジーの発信総合文化研究所紀要 27巻,5-15頁 (共著) 2010/03
論文	Alpha2-antiplasmin is associated with the progression of fibrosis Am J Pathol. 176巻 (1号),238-245頁 (共著) 2009/11
論文	Correlation Between Albuminuria and Spontaneous Platelet Microaggregate Formation in Type 2 Diabetic Patients Diabetes Care Vol.32 (No.11),2062-2067頁 (共著) 2009/11
論文	Abnormal production of macrophage inflammatory protein-1alpha by microglial cell lines derived from neonatal brains of sandhoff disease model mice J Neurochem. Vol.109 (No.5),1215-1224頁 (共著) 2009/06
論文	The absence of uPAR is associated with the progression of dermal fibrosis J Invest Dermatol. Vol.128 (No.12),2792-2797頁 (共著) 2008/12
論文	The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation Thromb Res. Vol.123 (No.2),336-341頁 (共著) 2008
論文	Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis J Thromb Haemost. Vol.5,c 2266-2273頁 (共著) 2007/11
論文	Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen Thromb Haemost. Vol.97 (No.5),795-802頁 (共著) 2007
論文	Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes Life Sci Vol.79 (No.12),1214-1220頁 (共著) 2006/08
論文	Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions J Thromb Haemost Vol.4 (No.7),1602-1610頁 (共著) 2006/07
論文	Alpha2-antiplasmin on cardiovascular diseases Curr Pharm Des. Vol.12 (No.7),841-847頁 2006/03
論文	Novel ideas of gene therapy for atherosclerosis: modulation of cellular signal transduction of TGF-beta family Curr Pharm Des. Vol.12 (No.7),877-886頁 (共著) 2006/03
論文	The possibility of novel antiplatelet peptides: the physiological effects of low molecular weight HSPs on platelets Curr Pharm Des. Vol.12 (No.7),887-892頁 (共著) 2006/03
論文	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase Life Sci. Vol.77 (1),96-107頁 (共著) 2005
論文	P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes J Clin Endocrinol Metab. Vol.90 (2),920-927頁 (共著) 2005
論文	Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells Arch Biochem Biophys. Vol.438 (2),137-145頁 (共著) 2005
論文	Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis through an independent fibrinolytic cascade Invest Ophthalmol Vis Sci. Vol.46 (4),1504-1507頁 (共著) 2005
論文	αB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB Arch Biochem Biophys. Vol.438 (2),111-118頁 (共著) 2005
論文	Effect of a synthetic matrix metalloproteinase inhibitor （ONO-4817） on neointima formation in hypercholesterolemic hamsters J Cardiovasc Pharmacol. Vol.44 (1),57-65頁 (共著) 2004/07
論文	Simvastatin enhances the regeneration of endothelial cells via VEGF secretion in injured arteries Journal of Cardiovascular Pharmacology Vol.43,333-340頁 (共著) 2004/03
論文	Platelet-derived growth factor-BB phosphorylates heat shock protein 27 in cardiac myocytes Journal of Celluluar Biochemistry Vol.91,316-324頁 (共著) 2004/02
論文	Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage Toxicol Appl Pharmacol. Vol.200 (1),48-53頁 (共著) 2004
論文	Vasopressin phosphorylates HSP27 in aortic smooth muscle cells J Cell Biochem. Vol.92 (6),1203-1211頁 (共著) 2004
論文	A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX Journal of Thrombosis and Haemostsis Vol.1,2636-2642頁 (共著) 2003/12
論文	Lack of alpha 2- antiplasmin promotes re- endothelialization via over-release of VEGF after vascular injury in mice Blood Vol.102 (10),3621-3628頁 (共著) 2003/11
論文	Alpha2-　antiplasmin plays a significant role in acute pulmonary embolism Journal of Thrombosis and Haemostasis Vol.1,1734-1739頁 (共著) 2003/08
論文	Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers Journal Clinical Pharmacology Vol.42,782-790頁 (共著) 2003/07
論文	Incadronate amplifies prostaglandin F2 alpha- induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity Journal of Biological Chemistry Vol.278,18930-18937頁 (共著) 2003/05
論文	Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells Biochemical and Biophysical Research Communications Vol.301,198-203頁 (共著) 2003/01
論文	HSP20, low-molecular- weight heat shock-related protein, acts extracellularly as a regulator of platelet functions: a novel defense mechanism Life Sciences Vol.72,113-124頁 (共著) 2002/12
論文	Lack of alpha 2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice Journal of Thrombosis and Thrombolysis Vol.4,205-211頁 (共著) 2002/12
論文	Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide Cell Signaling Vol.14,999-1004頁 (共著) 2002/12
論文	Lack of alpha2- antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction Blood Vol.100 (7),2487-2493頁 (共著) 2002/10
論文	Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells American Journal of Physiology Heart and Circlation Physiology Vol.283,H941-948頁 (共著) 2002/09
論文	Function of tissue-type plasminogen activator releaser on vascular endothelial cells and thrombolysis in vivo Thrombosis and Haemostasis Vol.87,1069-1074頁 (共著) 2002/07
論文	Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice Journal of Cardiovascular Pharmacology Vol.39,278-286頁 (共著) 2002/02
論文	Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells Journal of Endocrinology Vol.172,271-281頁 (共著) 2002/02
論文	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice Thrombosis and Haemostasis Vol.87,98-104頁 (共著) 2002/02
論文	Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells Journal of Cellular Biochemistry Vol.84,39-46頁 (共著) 2001/12
論文	Inhibition by adenylyl cyclase-　cAMP system of ET-1-induced HSP27 in osteoblasts American Journal of Physiology Endocrinology Metabolism Vol.281,E1260-1266頁 (共著) 2001/12
論文	Activation of p44/p42 mitogen-activated protein kinase limits triiodothyronine- stimulated alkaline phosphatase activity in osteoblasts Biochemical and Biophysical Research Communications Vol.286,1140-1143頁 (共著) 2001/08
論文	Mechanism of prostaglandin D(2)- stimulated heat shock protein 27 induction in osteoblasts Cell Signaling Vol.13,535-541頁 (共著) 2001/08
論文	Photochemically induced equilibrium dysfunction in the hamster model with evaluation by means of a new globe rotatory test system Annual Otol-Rhinology Laryngology Vol.110,758-764頁 (共著) 2001/08
論文	Involvement of p38 MAP kinase in TGF-beta- stimulated VEGF synthesis in aortic smooth muscle cells Journal of cellular Biochemistry Vol.82,591-598頁 (共著) 2001/07
論文	AlphaB-crystallin, a low-molecular-　weight heat shock protein, acts as a regulator of platelet function Cell Stress and Chaperon Vol.6,21-28頁 (共著) 2001/06
論文	Characterization of simple and reproducible vascular stenosis model in hyper- cholesterolemic hamsters Lipids Vol.36,453-460頁 (共著) 2001/05
論文	Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C Archives Biochemistry Biophysiology Vol.388,237-242頁 (共著) 2001/04
論文	Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas- mediated massive hepatic apoptosis Hepatology Vol.3,569-57頁 (共著) 2001/03
論文	Pharmacokinetics of a new parenteral oligosaccharide antibiotic, SCH27899 (Ziracin), in healthy subjects Antimicrobiological Agents Chemotherphy Vol.45,917-921頁 (共著) 2001/03
論文	tPA, but not uPA, significantly affects antithrombotic therapy by a glycoprotein IIb/IIIa antagonist, but not by a factor Xa inhibitor Journal of Cardiovascular Pharmacology Vol.36,770-775頁 (共著) 2000/12
論文	The interaction between components of the fibrinolytic system and GPIb/V/IX of platelets thrombus formation in mice British Journal of Pharmacology Vol.131,858-864頁 (共著) 2000/10
論文	Pharmacokinetics and tolerability of intravenous infusion of adenosine (SUNY4001) in healthy volunteers British Journal of Clinical Pharmacology Vol.50,177-181頁 (共著) 2000/08
論文	Transient ischemic injury in the rat retina caused by thrombotic occlusion-　thrombolytic reperfusion Investigated Ophthalmology and Visual Science Vol.41,2743-2747頁 (共著) 2000/08
論文	Usefulness of grading of neutrophil aggregate size by laser-light scattering technique for characterizing stimulatory and inhibitory effects of agents on aggregation Life Scienceｓ Vol.67,1525-1534頁 (共著) 2000/08
論文	Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase Cell Signaling Vol.12,375-380頁 (共著) 2000/07
論文	p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F2 hydrolysis Cell Signaling Vol.12,447-450頁 (共著) 2000/07
論文	Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice Thrombosis and Haemostasis Vol.83,605-609頁 (共著) 2000/04
論文	Small molecular weight heat shock-related protein, HSP20, exhibits an anti-platelet activity by inhibiting receptor-mediated calcium influx Life Scienceｓ Vol.66,PL7-12頁 (共著) 2000/03
論文	Measurement of furancarboxylic acid, a candidate for uremic toxin, in human serum, hair, and sweat, and analysis of pharmacological actions in vitro Arch Toxicology Vol.73,649-654頁 (共著) 2000/02
論文	p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells Hypertension Vol.35,673-678頁 (共著) 2000/02
論文	Comparison of the antithrombotic effects and bleeding risk of fractionated aurintricarboxylic acid and the GPIIb/IIIa antagonist GR144053 in a hamster model of stenosis Thrombosis Research Vol.95,49-61頁 (共著) 1999/10
論文	Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells Experimental Cell Research Vol.250,376-380頁 (共著) 1999/10
論文	Sphingosine 1-phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts Journal of Bone and Mineral Research Vol.14,1761-1767頁 (共著) 1999/09
論文	Comparative antiplatelet effects of aspirin, vapiprost and GR144053, a GPIIb/IIIa antagonist, with a special reference to the role of platelet microaggregates British Journal of Pharmacology Vol.127,1129-1134頁 (共著) 1999/07
論文	Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury Thrombosis and Haemostasis Vol.81,601-604頁 (共著) 1999/04
論文	Involvement of p42/p44 MAP kinase in endothelin-1- induced interleukin-6 synthesis in osteoblast-like cells Bone Vol.24,315-320頁 (共著) 1999/04
論文	Vasopressin stimulates the induction of heat shock protein 27 and alphaB- crystallin via protein kinase C activation in vascular smooth muscle cells Experimental Cell Research Vol.246,327-337頁 (共著) 1999/02
論文	Effect of propofol on arachidonate cascade by vasopressin in aortic smooth muscle cells: inhibition of PGI2 synthesis Anesthesiology Vol.90,215-224頁 (共著) 1999/01
論文	A heat shock-related protein, p20, plays an inhibitory role in platelet activation FEBS letters Vol.429,327-329頁 (共著) 1998/06
論文	Multiple inhibition of platelet activation by aurintricarboxylic acid prevents vascular stenosis after endothelial injury in hamster carotid artery Thrombosis and Haemostasis Vol.79,865-871頁 (共著) 1998/04
論文	GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the　injured carotid artery of the hamster British Journal of Pharmacology Vol.122,1099-1104頁 (共著) 1997/10
論文	Inhibition of von Willebrand factor binding to platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery Circulation Vol.96,1299-304頁 (共著) 1997/08
論文	Neointima formation in injured hamster carotid artery is effectively. prevented by the combination G4120 and quinapril Thrombosis and Haemostasis Vol.76,263-269頁 (共著) 1996/08
論文	Fast and reproducible vascular neointima formation in the hamster carotid artery: effects of trapidil and captopril Thrombosis and Haemostasis Vol.74,1591-1596頁 (共著) 1995/12
論文	Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation Circulation Vol.90,2203-2206頁 (共著) 1994/10
論文	Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator British Journal of Pharmacology Vol.106,533-538頁 (共著) 1992/06
論文	A novel and reproducible thrombus model in rats: evaluation of antithrombotic drugs in vivo 博士学位論文 (単著) 1992/03
論文	Photochemically induced thrombosis model in rat femoral artery and evaluation of effects of heparin and tissue-type plasminogen activator with use of this model Journal of Pharmacological and Toxicological Methods (formally Journal of Pharmacological Methods) (Vol.25),303-317頁 (共著) 1991/07
その他	脂肪細胞の分化・誘導における線溶系因子の機能解明と治療戦略的ストラテジーの確立文部科学省科学研究費補助金（基盤研究（C）） 2007
その他	Vascular remodelingと抗線溶系因子別冊・医学のあゆみVer3,177-181頁 2005
その他	骨髄液中の未分化間葉系細胞における線溶系各因子の役割の解明鈴木謙三記念医科学応用研究財団 2005
その他	骨髄液中の未分化間葉系細胞における線溶系各因子の役割の解明：細胞分化制御による病態治療への介入と薬理学的ストラテジーの確立文部科学省科学研究費補助金（基盤研究（C）） 2005
その他	Vascular redodelingにおけるalpha2-antiplasminの新たな役割血栓止血学雑誌 Vol.15,517-521頁 (共著) 2004
その他	急性虚血、血管病変におけるVEGFとalpha2-antiplasminの相互作用血栓止血学雑誌 Vol.14,277-279頁 (共著) 2004
その他	遺伝子改変動物から学ぶ血栓症、alpha2-antiplasmin deficient mice 血栓と循環 Vol.12,4-8頁 (共著) 2004
その他	A new aspect of alpha2-antiplasmin in vascular biology Resent Res. Devel. Cell. Biochem. Vol.1,21-31頁 (共著) 2003
その他	Novel physiological roles of low molecular weight HSPs 日薬理誌 Vol.121,21-25頁 (共著) 2003
その他	再生医療におけるプラスミンのVEGF制御機構の意義と役割の解明：α2-antiplasmin欠損マウスを用いての創薬への可能性追求と薬理学的アプローチ” 文部科学省科学研究費補助金（基盤研究（C）） 2003
その他	線溶系阻害因子（Serpins）の血栓形成における役割の解析：新規血栓症治療薬としての可能性金原一郎記念医学医療振興財団・基礎医学医療研究助成 2002
その他	新薬の老年者への適応(19)―15員環マクロライド系抗生物質（ジスロマック）老年消化器 Vol.13,65-67頁 (共著) 2001
その他	新薬の老年者への適応―デュロテップ・パッチ― 老年消化器ｘ Vol.14,21-25頁 (共著) 2001
その他	新薬の老年者への適応―ニコチネルＴＴＳ、禁煙補助剤老年消化器 Vol.13,217-219頁 (共著) 2001
その他	静脈血栓由来肺塞栓症の病態解明と予防・制御：治療薬開発への薬理学的アプローチ文部科学省 2001
その他	TSP欠損マウス日薬理誌 Vol.115,62-63頁 (単著) 2000
その他	線溶系ノックアウトマウスが示す新薬への可能性 Pharma D Vol.2,30 (共著) 2000
その他	線溶系ノックアウトマウスの薬理学への応用日薬理誌 Vol.115,365-366頁 (共著) 2000
その他	血小板膜蛋白受容体の薬理学的意義 Medical Academy News Vol.724, 10 (単著) 2000
その他	血小板膜蛋白受容体（インテグリン機構）の薬理学的意義日薬理誌 Vol.115,143-159頁 (共著) 2000
その他	高脂血症と血管狭窄治療 Vol.82,115-117頁 (共著) 2000