研究者データベース - 喜里山　暁子

キリヤマ　アキコ KIRIYAMA Akiko
喜里山　暁子

所属同志社女子大学薬学部医療薬学科

職種教授

著書・論文歴
著書	ナノバイオテクノロジーの応用展開～ナノマテリアルの創製とデバイス開発～,1-249頁 (共著) 2005/09
論文	Pharmacokinetic and Hypoglycemic Analysis of Glimepiride and Bezafibrate: Mathematical Modeling and Simulation of Co-administration with Experimental Validation The Harris Science Review of Doshisha University 65 (4),121-131頁 (共著) 2025/01
論文	Physiologically Based Pharmacokinetic Modeling using Various Pharmacokinetic Models to Predict the Pharmacokinetics of the Anti-tumor Agent, Dacarbazine, in Rats The Harris Science Review of Doshisha University 65 (4),132-141頁 (共著) 2025/01
論文	Pharmacokinetic–Pharmacodynamic analyses of the antidiabetic drug, nateglinide, in Goto-Kakizaki rats based on pharmacological mechanism Journal of Drug Metabolism & Toxicology 15 (4),1000350 (単著) 2024/12
論文	Tumoral Pharmacokinetic–Pharmacodynamic Simulation of Doxorubicin-Encapsulated Polymeric Micelles Using a Tissue-Isolated Tumor Perfusion System Molecular Pharmaceutics 21 (11),5736-5748頁 (共著) 2024/09
論文	Left-Right Difference in Brain Pharmacokinetics Following Nasal Administration Via One-Site Nostrils Journal of Pharmaceutical Sciences 113 (8),2633-2640頁 (共著) 2024/08
論文	Exploring the multiple effects of nifedipine and captopril administration in spontaneously hypertensive rats through pharmacokinetic-pharmacodynamic analyses Pharmacology Research & Perspectives 12 (4),e1249 (共著) 2024/07
論文	Pharmacokinetic-Pharmacodynamic Analyses of the Antidiabetic Drug, Nateglinide, in Goto-Kakizaki Rats Based on Pharmacological Mechanism Journal of Drug Metabolism & Toxicology 15 (2),1000330 (共著) 2024/07
論文	Pharmacokinetic-Pharmacodynamic Analysis of pH-Responsive Doxorubicin-Releasing Micelles with Anticancer Activity Molecular pharmaceutics 21 (7),3173-3185頁 (共著) 2024/07
論文	ラットを用いた抗糖尿病薬・グリメピリドと抗脂血症薬・ベザフィブラートの併用効果－薬物動態学/薬力学解析を用いた基礎的検討－同志社女子大学総合文化研究所紀要第41巻,45-56頁 (共著) 2024/07
論文	Variations in the inner core affect the pharmacokinetics of indomethacin-encapsulated polymeric micelles International Journal of Pharmaceutics 654,123933 (共著) 2024/04
論文	Evaluation of anticancer effect of micelle-encapsulated doxorubicin using gamma-distributed delay model Journal of Drug Delivery Science and Technology 91,105244 (共著) 2024/01
論文	Interplay of UDP‑Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil Clinical Pharmacokinetics 63 (1),43-56頁 (共著) 2024/01
論文	A Synthetic Porphyrin as an Effective Dual Antidote against Carbon Monoxide and Cyanide Poisoning PNAS 120 (9),e2209924120 (共著) 2023/02
論文	Pharmacokinetic/pharmacodynamic models of an Alzheimer's drug, donepezil, in rats Drug Metabolism and Disposition 51 (2),329-337頁 (共著) 2023/02
論文	抗悪性腫瘍薬・ダカルバジンのラットを用いた薬物動態学的モデル解析の基礎的検討同志社女子大学　総合文化研究所紀要第39巻,118-129頁 (共著) 2022/07
論文	体内動態を効果へとつなぐアルツハイマー病治療薬の薬物動態学/薬力学解析と薬物相互作用 YAKUGAKU ZASSHI 141 (6),831-833頁 (単著) 2021/06
論文	α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline. Mol. Brain 13 (1),140 (共著) 2020/10
論文	Transnasal Delivery of the Peptide Agonist Specific to Neuromedin-U Receptor 2 to the Brain for the Treatment of Obesity. Mol. Pharmaceutics 17 (1),32-39頁 (共著) 2020/01
論文	Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per-O-Methylated β-Cyclodextrin Cavity in Serum, Blood, and Urine. Chem Asian J. 14 (19),3320-3328頁 (共著) 2019/08
論文	Novel strategy for the systemic delivery of furosemide based on a new drug transport mechanism Biological and Pharmaceutical Bulletin 41 (12),1769-1777頁 (共著) 2018/12
論文	Quantitative Estimation of the Effect of Nasal Mucociliary Function on In Vivo Absorption of Norfloxacin after Intranasal Administration to Rats Molecular Pharmaceutics 15 (10),4462-4469頁 (共著) 2018/10
論文	The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption European Journal of Pharmaceutical Sciences 117,21-26頁 (共著) 2018/05
論文	Delivery of oxytocin to the brain for the treatment of autism spectrum disorder by nasal application Molecular Pharmaceutics 15 (3),1105-1111頁 (共著) 2018/03
論文	Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles. European Journal of Pharmaceutics and Biopharmaceutics 122 (1),1-5頁 (共著) 2018/01
論文	Usefulness of Two-Compartment Model-Assisted and Static Overall Inhibitory-Activity Method for Prediction of Drug-Drug Interaction Biological and Pharmaceutical Bulletin 40 (12),2024-2037頁 (共著) 2017/12
論文	Pharmacokinetic-Pharmacodynamic Analyses of Anti-diabetes, Glimepiride: Comparison of the Streptozotocin-Induced Diabetic, GK, and Wistar Rats Journal of Drug Metabolism and Toxicology 8 (2),1000229 (共著) 2017/08
論文	Simulations of cytochrome P450 3A4-mediated drug-drug interactions by simple two-compartment model-assisted static method Journal of Pharmaceutical Sciences 106 (5),1426-1438頁 (共著) 2017/05
論文	Pharmacokinetic-pharmacodynamic analyses of antihypertensive drugs, nifedipine and propranolol, in spontaneously hypertensive rats to investigate characteristics of effect and side effects Regulatory Toxicology and Pharmacology 76 (1),21-29頁 (共著) 2016/01
論文	Preparation and pharmaceutical evaluation of acetaminophen nano-fiber tablets: Application of a solvent-based electrospinning method for tableting Biomedicine and Pharmacotherapy 78 (1),14-22頁 (共著) 2016/01
論文	Intrinsic cell permeability of the GAGA zinc finger protein into HeLa cells. Biochem. Biophys. Re.s Commun. 464 (4),1034-1039頁 (共著) 2015/09
論文	Availability of polymeric nanoparticles for specific enhanced and targeted drug delivery Therapeutic Delivery 4 (10),1261-1278頁 (共著) 2013/10
論文	Effects of physiological and biochemical factors based on aging, pathological conditions and drug combinations on propranolol pharmacokinetics using physiologically-based pharmacokinetic model in humans Biomedicine & Aging Pathology 3 (3),107-114頁 (共著) 2013/03
論文	Analysis of factors determining incomplete intestinal drug absorption as observed in cyclosporine formulations by use of tube model incorporated Nernst Equation Drug Metabolism Reviews 42巻 (Suppl 1),43-44頁 (共著) 2010/08
論文	A diatomic molecule receptor that removes CO in a living organism. Angewandte Chemie-International Edition in English 49 (7),1312-1315頁 (共著) 2010/07
論文	Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of an　HIV-1 Envelope and Their Antiviral Activity Chem. Asian J. 5,825-834頁 (共著) 2010/04
論文	Prediction of intestinal and hepatic first-pass effects in human using data of caco-2 cell permeability and oral clearance Drug Metabolism Reviews Vol.41 (Suppl 1),28 (共著) 2009/10
論文	Pharmacokinetic Profiles of Coenzyme Q10: Absorption of Three Different Oral Formulations in Rats Journal of Health Science Vol.55 (No.4),540-548頁 (共著) 2009/05
論文	How greatly is the magnitude of drug-drug interaction influenced by administration time of inhibitor?: simulation of interaction after co-administration of melatonin with fluvoxamine by Dynamo-PK analysis method Drug Metabolism Reviews Vol.40 (Suppl 1),80 (共著) 2008/10
論文	Analysis of hepatic metabolism affecting pharmacokinetics of propranolol in humans International Journal of Pharmaceutics Vol.349 (No.1-2),53-60頁 (共著) 2008/01
論文	Effect of Physiological and Biochemical Parameters on Propranolol Pharmacokinetics Using a Physiologically-Based Pharmacokinetic Model in Humans Drug Metabolism Reviews Vol.39 (Supple 1),154 (共著) 2007/10
論文	How greatly is the magnitude of drug-drug interaction influenced by factors other than Imax/Ki of inhibitor?: simulation of interaction of rapidly-eliminating drugs with fluvoxamine by Dynamo-PK analysis method Drug Metabolism Reviews. Supple.1 39 (Suppl 1),124 (共著) 2007/10
論文	A Multi-sinusoidal Compartment Model as an Alternative to the Dispersion Model for Hepatic Extraction Kinetic Analysis 同志社女子大学学術研究年報 57巻,105-113頁 (共著) 2006/12
論文	Twoコンパートメント・ファーマコキネティック・モデル（TCBPK）を用いたダイナモPK―プロプラノロールの動態に及ぼす食事の効果のシミュレーション― 同志社女子大学総合文化研究所紀要 23巻,109-117頁 (共著) 2006/03
論文	Multi-compartment model as a possible alternative to dispersion model for hepatic extraction kinetic analysis Drug Metabolism Reviews Vol.37 (Suppl 2),207-208頁 (共著) 2005/09
論文	Transport of macromolecules by M-cells: Study with in vitro M-cell model Drug Metabolism Reviews Vol.37 (Suppl 2),274 (共著) 2005/09
論文	Pharmacokinetics of an HIV-1 protease inhibitor, KNI 272, in animals. 京都薬科大学　博士学位論文 (単著) 1999/09
論文	Metabolic characterization of a tripeptide HIV-1 protease inhibitor, KNI-272, in rat liver microsomes Antimicrob. Agents Chemother. Vol.43,549-556頁 (共著) 1999/05
論文	Physiologically based pharmacokinetics of KNI-272, a tripeptide HIV-1 protease inhibitor Biopharm. Drug Dispos. Vol.20,199-205頁 (共著) 1999/04
論文	Binding characteristics of KNI-272 to plasma proteins, a new potent tripeptide HIV protease inhibitor Biopharm. Drug Dispos. Vol.17,739-751頁 (共著) 1996/09
論文	The bioavailability of oral dosage forms of a new HIV-1 protease inhibitor, KNI-272, in beagle dogs Biopharm. Drug Dispos Vol.17,125-134頁 (共著) 1996/02
論文	Absorption of new HIV-1 protease inhibitor, KNI-272, after intraduodenal and intragastric administrations to rats: Effect of solvent Biopharm. Drug Dispos Vol.16,269-277頁 (共著) 1995/04
論文	Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV-1 protease inhibitor, KNI-272, in rats after intravenous administration. Biopharmaceutics ＆ Drug Disposition 15 (7),617-626頁 (共著) 1994/07
論文	HIVプロテアーゼ阻害剤・KNI-272のラットにおける血中動態,尿中および胆汁中排泄の検討臨床薬理 25 (1),159-160頁 (共著) 1994/01
論文	Comparison of a new orally potent tripeptide HIV-1 protease inhibitor (anti-AIDS drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations. Biopharmaceutics ＆ Drug Disposition 14 (8),697-707頁 (共著) 1993/08
論文	Distribution characteristics of immunosuppressants FK506 and cyclosporin A in the blood compartment. Biopharmaceutics ＆ Drug Disposition 14 (8),659-672頁 (共著) 1993/08
論文	Pharmacokinetic study of a tripeptide HIV-1 protease inhibitor, KNI-174, in rats after intravenous and intraduodenal administrations. Biopharmaceutics ＆ Drug Disposition 14 (3),199-207頁 (共著) 1993/03
論文	HIVプロテアーゼ阻害剤・KNI-272のHPLCによる血漿中分析法とラットにおける血中動態臨床薬理 24 (1),105-106頁 (共著) 1993/01
論文	Stereoselectivity in N-dealkylation of disopyramide enantiomers in mouse hepatic microsomes. 薬学雑誌 112,61-64頁 (共著) 1992/12
論文	Effect of organic acids, trypsin inhibitors and dietary protein on the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. International Journal of Pharmaceutics 81 (2),133-141頁 (共著) 1992/02
論文	免疫抑制剤シクロスポリンAとFK506のラット、イヌおよびヒトにおける血液内分布の比較臨床薬理 23 (1),69-70頁 (共著) 1992/01
論文	Synthesis of -(methylthio) arylacetamides and their conversion into some biologically active arylethylamides. Chemical Pharmaceutical Bullletin 37,3396-3398頁 (共著) 1989/12
その他	生理学的モデルを用いたヒト血漿中薬物濃度の新しい予測法ファルマシア 42巻 (10号),1030 (単著) 2006/10
その他	抗AIDS薬AZTとddIの併用療法－薬物相互作用と毒性ファルマシア 31 (2),194-195頁 (単著) 1995/02