研究者データベース - 根木　滋

ネギ　シゲル NEGI Shigeru
根木　滋

所属同志社女子大学薬学部医療薬学科

職種教授

著書・論文歴
著書	“Non-FokI-based zinc finger nuclease” in Engineered Zinc Finger proteins <Eds. by J. Mackay and D. Segal> 649巻 (共著) 2010/10
論文	Binding mechanism of adenylate kinase-specific monobodies FEBS Lett. Vol. 599,1948-1963頁 (共著) 2025/05/21
論文	The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications J Biol Inorg Chem. Vol. 28,249-261頁 (共著) 2023/04/28
論文	A Synthetic Porphyrin as an Effective Dual Antidote against Carbon Monoxide and Cyanide Poisoning The Proceedings of the National Academy of Sciences Vol. 120 (No. 9),e2209924120 (共著) 2023/02/28
論文	Creation and Biological Application of Intelligent Zinc Finger Proteins The Harris Science Review of Doshisha University Vol .63 (No. 4),55-62頁 (共著) 2023/02/13
論文	Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability Chemistry Letters Vol. 52 (No. 2),75-78頁 (共著) 2022/12/24
論文	Monolayer formation and chiral recognition of binaphthyl amphiphiles at the air–water interface Bulletin of the Chemical Society of Japan Vol .96 (No. 1),48-56頁 (共著) 2022/12/24
論文	Highly Ordered Monolayers of an Optically Active Amphiphilic Pyrene Derivative at the Air–Water Interface Bulletin of the Chemical Society of Japan Vol. 95 (No. 11),1537-1545頁 (共著) 2022/10/07
論文	ペプチド転移酵素Sortase Aが触媒するtranspeptidation反応に対するCa2+濃度,反応温度,E105点変異,外因性金属イオンの効果に関する研究 Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women's College of Liberal Arts Vol.39,141-150頁 (共著) 2022/07/29
論文	Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage International Journal of Molecular Sciences Vol. 23 (No.14),1-16頁 (共著) 2022/07/15
論文	Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability RSC Chemical Biology Vol. 3,1076-1084頁 (共著) 2022/07/13
論文	Transpeptidation reaction mediated by ligand- and metal cofactor-substituted Sortase A from Staphylococcus aureus Bulletin of the Chemical Society of Japan Vol. 95 (No. 7),1025-1031頁 (共著) 2022/06/26
論文	Involvement of Trace Metals in the Reduction of Disulfide Bonds by Glutathione. The Harris Science Review of Doshisha University. Vol.63 (No. 1),45-49頁 (共著) 2022/05/12
論文	Deciphering the Molecular Mechanism Underlying Oxidation Reactions of Zinc Finger Proteins Using H2O2. Peptide Science Vol. 58,89-92頁 (共著) 2021/03
論文	The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis Journal of Biological Chemistry Vol.296,1-13頁 (共著) 2021/01/16
論文	Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per-O-Methylated β-Cyclodextrin Cavity in Serum, Blood, and Urine Chemistry – An Asian Journal Vol.14,3320-3328頁 (共著) 2019/10/01
論文	Circadian clock disruption by selective removal of endogenous carbon monoxide Scientific reports Vol.8 (No.11996),1-12頁 (共著) 2018/08/10
論文	Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-permeable Hemoprotein-model Complexes Journal of the American Chemical Society VOl. 139 (No. 16),5984-5991頁 (共著) 2017/04/07
論文	Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood. J Am Chem Soc. Vo. 138 (No. 16),5417-5425頁 (共著) 2016/04/08
論文	Efficient cleavage of DNA oligonucleotides by a non-FokI-type zinc　finger nuclease containing one His4-type finger domain derived from the first　finger domain of Sp1 Bioorganic & Medicinal Chemistry Letter Vol.25 (No. 19),4074-4077頁 (共著) 2015/10/01
論文	Intrinsic cell permeability of the GAGA zinc finger protein into HeLa Biochemical and Biophysical Research Communications Vol. 464 (No. 4),1034-1039頁 (共著) 2015/09/04
論文	Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin Chemical Communications Vol. 51 (No. 12),2421-2424頁 (共著) 2015/02/11
論文	Specific microfluidic behavior of ternary mixed carrier solvents of water-acetonitrile-ethyl acetate in open-tubular capillary chromatography and the chromatograms Analytical Methods Vol. 4,3884-3890頁 (共著) 2012/09/12
論文	Zn(II) Binding and DNA Binding Properties of Ligand-Substituted　CXHH-Type Zinc Finger Proteins Biochemistry Voi. 51 (No. 16),3342-3348頁 (共著) 2012/04/06
論文	Rational design of DNA sequence-specific zinc fingers FEBS Letters Vol. 586 (No. 6),918-923頁 (共著) 2012/02/23
論文	An arginine residue instead of a conserved leucine residue in the　recognition helix of the finger 3 of Zif268 stabilizes the domain structure　and mediates DNA binding Biochemistry Vol. 50 (No. 28),6266-6272頁 (共著) 2011/07/19
論文	Zinc finger-zinc finger interaction between the transcription factors, GATA-1and Sp1 Biochemical and Biophysical Research Communications, Vol. 400 (No.4),625-630頁 (共著) 2010/08/31
論文	Cytochrome C polymerization by successive domain swapping at the C-termina helix Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (No. 29),12854-12859頁 (共著) 2010/07/06
論文	Binding of multivalent anionic porphyrins to V3 loop fragment of HIV-1 and their antiviral activity Chemistry Asian Journa Vol. 5 (No. 4),825-834頁 (共著) 2010/03/30
論文	A diatomic molecule receptor that removes CO in a living organism Angewandte Chemie International Edition Vol. 49 (No. 7),1312-1315頁 (共著) 2010/02/01
論文	Novel zinc finger nuclease created by combining the Cys2His2- and His4-type zinc finger domains Bioorganic & Medicinal Chemistry Letters Vol.19 (No. 10),2789-2791頁 (共著) 2009/05/26
論文	Effects of Bulkiness and Hydrophobicity of an Aliphatic Amino Acid in the Recognition Helix of the GAGA Zinc Finger on the Stability of the Hydrophobic Core and DNA Binding Affinity Biochemistry Vol.47 (No. 45),11717-11724頁 (共著) 2008/10/15
論文	New Redesigned Zinc-Finger Proteins: Design Strategy and Its application Chemistry-A European Journal Vol.14,3236-3249頁 (共著) 2008/03/28
論文	DNA-Binding Ability of GAGA Zinc Finger Depends on the Nature of Amino Acids Present in the β-Hairpin Biochemistry Vol. 46 (No. 25),7506-7513頁 (共著) 2007/05/31
論文	Effect of aromatic amino acid, phenylalanine, substitution in the beta-hairpin region of GAGA zinc finger on DNA binding Peptide Science Vol. 2006,166-167頁 (共著) 2006/11
論文	Metal preference and DNA-binding properties of C2H2-type zinc finger peptide from GAGA transcription factor Peptide Science,105-106頁 (共著) 2006/11
論文	Rational design of a porphyrin binding peptide as heme model Peptide Science,103-104頁 (共著) 2006/11
論文	Designer Zinc Finger Proteins: Tools for Creating Artificial DNA-Binding Functional Proteins Accounts of Chemical Research Vol.39 (No.1),45-51頁 (共著) 2006/10
論文	Biomolecular mirror-image recognition: reciprocal chiral-specific DNA binding of synthetic enantiomers of zinc finger domain from GAGA factor Chirality Vol.18 (No.4),254-258頁 (共著) 2006/01
論文	Site-specific DNA cleavage by artificial zinc finger-type nuclease with cerium-binding peptide Biochem. Biophys. Res. Commun. Vol. 330 (No. 1),247-252頁 (共著) 2005/04/29
論文	Mirror-image recognition in peptide-DNA interaction Peptide Science Vol. 2005,93-96頁 (共著) 2005/01
論文	Creation and Characteristics of Unnatural CysHis3-Type Zinc Finger Protein Biochem. Biophys. Res. Commun. Vol 325 (N0. 2),432-425頁 (共著) 2004/12/10
論文	Protein folding by the effects of macromolecular crowding Protein Sci. Vol. 13 (No. 1),125-133頁 (共著) 2004/01/13
論文	Metal Coordination and Stacking Effects in Supramolecular Catalysis. Effects of Structural Variations of Copper Complexes for the Hydrolysis of Phosphate Esters TETRAHEDRON LETTERS Vol.　43 (No. 3),411-414頁 (共著) 2002/01/14
論文	Hydrogen-Bonded Complexes of Carboxylate Anions and Dextrins in an Aprotic Polar Solvent Eur.J.Org.Chem. Vol. 43 (No. 19),3689-3694頁 (共著) 2001/09/10
論文	Effects of Anions in Subphases on Langmuir Monolayer of N,N-Dimethyl-1-octadecanamine Bull. Chem. Soc. Jpn. Vol. 73 (No. 4),977-984頁 (共著) 2000/02/28
論文	Chiral recognition of an anionic tetrahelicene by native cyclodextrins. Enantioselectivity dominated by location of a hydrophilic group of the guest in a cyclodextrin cavity Journal of the Chemical Society, Perkin Transactions 2 No. 2 (1),15-22頁 (共著) 1999/01
論文	Chiral recognition of 1-(4-quinolyl)ethanol by permethylated α-cyclodextrin Journal of Chemical Research,750-751頁 (共著) 1998/09/01
論文	Self-Aggregation of Cationic Porphyrins in Water. Can Stacking Interaction Overcome Electrostatic Repulsive Force? Journal of Physical Chemistry A Vol. 101 (N0. 34),6118-6124頁 (共著) 1998/08/01
論文	Optical resolution of 1- arylethanols using transesterification catalyzed by lipases Enantiomer Vol. 2 (No. 3-4),261-266頁 (共著) 1997/10
論文	Chiral Recognition of Tetrahelicene Dicarboxylic Acid by Linear Dextrins Chemistry Letters Voi. 26 (No. 8),715-716頁 (共著) 1997/08
論文	Recognition of Helicity by Native Cyclodextrins. Highly Enantioselective Complexation of Tetrahelicene Dicarboxylic Acid with β-Cyclodextrin Chemistry Letters Vol. 27 (No. 2),151-152頁 (共著) 1997/02
論文	Mechanism for binding to the flexible cavity of permethylated α-cyclodextrin Journal of Inclusion Phenomena and Molecular Recognition in Chemistry Vol. 22,285-298頁 (共著) 1995/12
その他	新機能性亜鉛フィンガータンパク質のデザインと医学・薬学領域への展開ファルマシア Vol. 43,527-532頁 (共著) 2007/06
その他	人工亜鉛フィンガーによる遺伝子発現の制御－人工制限酵素から遺伝子治療まで化学 Vol. 61,68-69頁 (共著) 2006/08
その他	遺伝子を標的とする亜鉛フィンガーのタンパク質工学、人工亜鉛フィンガータンパク質の創製と機能化学工業 (共著) 2006/07