研究者データベース - 菅野　陽介

カンノ　ヨウスケ KANNO Yosuke
菅野　陽介

所属同志社女子大学薬学部医療薬学科

職種特別任用助教（有期）

著書・論文歴
著書	Effect of Alpha2-Antiplasmin on Tissue Remodeling.,319 (共著) 2012
著書	Proteins Researcher Biographical Sketches and Research Summaries (Protein Science and Engineering: Protein Biochemistry, Synthesis, Structure and Cell （1ST）,319 (共著) 2012
著書	Effect of Alpha2-Antiplasmin on Tissue Remodeling.,229 (共著) 2010
著書	SERPINS AND PROTEIN KINASE INHIBITORS: NOVEL FUNCTIONS, STRUCTURAL FEATURES AND MOLECULAR MECHANISMS,229 (共著) 2010
論文	MicroRNA-30c attenuates fibrosis progression and vascular dysfunction in systemic sclerosis model mice. Mol Biol Rep. 2021 (共著) 2021/04
論文	α2AP is associated with the development of lupus nephritis through the regulation of plasmin inhibition and inflammatory responses. Immun Inflamm Dis. 8,267-278.頁 (共著) 2020/09
論文	Alternatively activated macrophages are associated with the α2AP production that occurs with the development of dermal fibrosis : The role of alternatively activated macrophages on the development of fibrosis. Arthritis Res Ther. 22,76 (共著) 2020/04
論文	Decrease in matrix metalloproteinase‑3 activity in systemic sclerosis fibroblasts causes α2‑antiplasmin and extracellular matrix deposition, and contributes to fibrosis development Molecular Medicine REPORTS 22,3001-3007頁 (共著) 2020
論文	The Role of Fibrinolytic Regulators in Vascular Dysfunction of Systemic Sclerosis Int. J. Mol. Sci. 20 (3),619 (単著) 2019/01
論文	α2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function. Int J Mol Med. 40,854-858頁 2017/07
論文	uPA-derived peptide, Å6 is involved in the suppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and the resultant bone loss. Immun Inflamm Dis. (共著) 2017/05
論文	α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis. Arthritis Res Ther. 19,22 (共著) 2017/02
論文	α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis. Arthritis Res Ther. 19 (1),22 (共著) 2017/02
論文	Plasminogen deficiency is associated with improved glucose tolerance, and lower DPP-4 activity Diabetes Research and Clinical Practice 120,190-193頁 2016/08
論文	The blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathway Immunity, Inflammation and Disease 4,338-349頁 (共著) 2016/08
論文	The Antifibrotic Effect of α2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis. J Invest Dermatol. 136 (4),762-9.頁 (共著) 2016
論文	uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis. Int J Biol Sci. 12 (1),63-71頁 2016
論文	Alpha2-antiplasmin: A New Target for Fibrotic Diseases Biochemistry & Analytical Biochemistry 4,194 2015
論文	Enhancement by Uridine Diphosphate of Macrophage Inflammatory Protein-1 Alpha Production in Microglia Derived from Sandhoff Disease Model Mice. JIMD Rep.,1-9頁 2015
論文	α2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction Sci Rep. 4,5967 (共著) 2014/08/06
論文	Altered behavior in mice with deletion of the alpha2-antiplasmin gene. PLoS One. 9 (5),e97947 (共著) 2014/05
論文	Cilostazol attenuates spontaneous microaggregation of platelets in type 2 diabetic patients with insufficient platelet response to aspirin. Diabetes Care. 36 (7),e92-3.頁 (共著) 2013/07
論文	Involvement of alpha2-antiplasmin in dendritic growth in hippocampal neurons Journal of Neurochemistry 126巻 (1号),58-69.頁 (共著) 2013/07
論文	Alpha2-antiplasmin regulates the development of dermal fibrosis by PGF2a synthesis through ATGL/iPLA2. Arthritis Rheum. 65巻 (2号),492-502.頁 (共著) 2013/01
論文	Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway. Biometals 24 (5),847-56.頁 (共著) 2011/10
論文	Plasminogen/Plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function J Biol Chem. 286巻 (11号),8952-8960頁 (共著) 2011/03
論文	The absence of urokinase type plasminogen activator receptor is involved in insulin-independent glucose metabolism Journal of Cardiovascular Pharmacology 57巻 (3号),334-339頁 (共著) 2011/03
論文	Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway PLoS ONE 6巻,e16269 (共著) 2011/01
論文	uPAR is associated with the development of adipose tissue Thrombosis and Heamostasis 104巻 (6号),1124-1132頁 (共著) 2010/12
論文	Alpha2-antiplasmin is associated with the progression of fibrosis Am J Pathol. Vol.176,238-245頁 (共著) 2010/01
論文	Structural Basis of Alternative DNA Recognition by Maf Transcription Factors Mol Cell Biol. Vol.29 (No.23),6232-6244頁 (共著) 2009/12
論文	Correlation between albuminuria and spontaneous platelet micro-aggregate formation in type 2 diabetic patients Diabetes Care. Vol.32 (No.11),2062-2067頁 (共著) 2009/11
論文	組織の線維化における線維素溶解系因子の役割日本血栓止血学会誌 20巻 (1号),23-26頁 (共著) 2009/02
論文	The absence of uPAR inhibits insulin-induced vascular smooth muscle cell migration and proliferations Thromb Res. Vol.123 (No.2),336-341頁 (共著) 2008/12
論文	The absence of uPAR is associated with the progression of dermal fibrosis J Invest Dermatol. Vol.128,2792-2797頁 (共著) 2008/12
論文	Nitric oxide regulates vascular calcification by interfering with TGF-β signaling Cardiovascular Reserch Vol.77 (No.1),221-230頁 (共著) 2008/01
論文	Alpha2-antiplasmin is involved in the production of TGF-β1 and fibrosis Journal of Thrombosis and Haemostasis Vol.5 (No.11),2266-2273頁 (共著) 2007/11
論文	Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells Journal of Biological Chemistry Vol.282 (No.11),8134-8141頁 (共著) 2007/03
論文	Lack of α2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions Journal of Thrombosis and Haemostasis,1602-10頁 (共著) 2006/07
論文	Arginine-specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leukocyte protease inhibitor in periodontal tissue. Clin. Exp. Immunol. 145,545-54.頁 2006
論文	The Possibility of Novel Antiplatelet Peptides: The Physiological Effects of Low Molecular Weight HSPs on Platelets. Current Pharmaceutical Design 12,887-92頁 2006
論文	Adenylyl cyclase-cAMP System Inhibits Thyroid Hormone-Stimulated Osteocalcin Synthesis in Osteoblasts Molecular and Cellular Endocrinology Vol.229,75-82頁 (共著) 2005
論文	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: Function at a point downstream from p38 MAP kinase. Life Sci. 77,96-107頁 2005
論文	alphaB-crystallin is phosphorylated during myocardial infarction: Involvement of platelet-derived growth factor-BB. Arch Biochem Biophys. 438,111-8頁 2005
論文	Methotrexate suppresses inflammatory agonists- induced interleukin-6 synthesis in osteoblasts The Journal of Rheumatology Vol.32,787-95頁 (共著) 2005
論文	Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells. Arch Biochem Biophys. 438,137-45頁 2005
論文	PPAR-gamma ligands up-regulate basic fibroblast growth factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts. Biochem Biophys Res Commun. 328,137-43頁 2005
論文	SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblasts. Hormone and metabolic research Vol.37,140-145頁 2005
論文	Tiludronate inhibits prostaglandin F(2alpha)-induced vascular endothelial growth factor synthesis in osteoblasts. Mol Cell Endocrinol. 236,59-66頁 2005
論文	Interleukin （IL）-17 Enhances Tumor Necrosis Factor-α-Stimulated IL-6 Synthesis via p38 Mitogen-Activated Protein Kinase in Osteoblasts Journal of Cellular Biochemistry Vol.91,1053-61頁 (共著) 2004
論文	Involvement of SAPK/JNK in prostaglandin E1-induced VEGF synthesis in osteoblasts like cells Molecular and Cellular Endocrinology Vol.220,89-95頁 (共著) 2004
論文	退行期骨粗鬆症とその治療東海産婦人科学会雑誌 40巻,9-13頁 (共著) 2004
その他	The roles of α2AP in the pathogenesis of systemic sclerosis Atlas of science (単著) 2016/04
その他	日本血栓止血学会誌　ジャーナルクラブ日本血栓止血学会誌 21 (3),355 (単著) 2010
その他	日本血栓止血学会誌　ジャーナルクラブ日本血栓止血学会誌 20 (5),561 (単著) 2009
その他	Effect of Nitric Oxide on the Development of Vascular Calcification INTERNATIONAL ATHEROSCLEROSIS SOCIETY (IAS) website, http://www.athero.org/ 2008
その他	日本血栓止血学会誌　ジャーナルクラブ日本血栓止血学会誌 19 (3),437 2008
その他	日本血栓止血学会誌　ジャーナルクラブ日本血栓止血学会誌 18 (6),665 2007