研究者データベース - 前川　京子

マエカワ　ケイコ MAEKAWA keiko
前川　京子

所属同志社女子大学薬学部医療薬学科

職種教授

著書・論文歴
論文	Structural and biophysical analysis of cytochrome P450 2C914 and 27 variants in complex with losartan. Journal of inorganic biochemistry 258,112622 (共著) 2024/09
論文	Quality Evaluation of Gentamicin Sulfate Reference Standards in Japanese Pharmacopoeia Using Hydrophilic Interaction Chromatography Combined With Tandem Mass Spectrometry. Journal of AOAC International 107 (2),234-241 (共著) 2024/03
論文	Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen. RSC medicinal chemistry 14 (12),2583-2592 (共著) 2023/12
論文	Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese patients. Hepatology research : the official journal of the Japan Society of Hepatology 53 (5),440-449 (共著) 2023/05
論文	Validation of a genotyping technique for a surrogate marker of HLA-B∗58:01 for allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in the Japanese population. Drug metabolism and pharmacokinetics 49,100495 (共著) 2023/04
論文	Impact of the TRPV2 Inhibitor on Advanced Heart Failure in Patients with Muscular Dystrophy: Exploratory Study of Biomarkers Related to the Efficacy of Tranilast. International journal of molecular sciences 24 (3) (共著) 2023/01
論文	Screening and quantification of undeclared PGF2α analogs in eyelash-enhancing cosmetic serums using LC-MS/MS. Journal of pharmaceutical and biomedical analysis 219,114940 (共著) 2022/09
論文	Iridium-catalyzed α-selective deuteration of alcohols. Chemical science 13 (30),8744-8751 (共著) 2022/08
論文	Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors. Drug metabolism and pharmacokinetics 43,100441 (共著) 2022/04
論文	Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism. Molecular pharmacology 98 (5),529-539 (共著) 2020/11
論文	Hepatic Adaptation to Therapeutic Doses of Acetaminophen: An Exploratory Study in Healthy Individuals. Clinical therapeutics 42 (7),1276-1291.e1 (共著) 2020/07
論文	Clinical study designs and patient selection methods based on genomic biomarkers: Points-to-consider documents. Drug metabolism and pharmacokinetics 35 (2),187-190 (共著) 2020/04
論文	Lipidomic signatures of aortic media from patients with atherosclerotic and nonatherosclerotic aneurysms. Scientific reports 9 (1),15472 (共著) 2019/10
論文	Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma. Cancer science 110 (10),3267-3274 (共著) 2019/10
論文	Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9. Biochemistry 56 (41),5476-5480 (共著) 2017/10
論文	Influences of Long-Term, High-Dose Acetaminophen Administration on Liver Function Markers in Healthy Japanese Adults 臨床薬理 48 (5),153-159頁 (共著) 2017/09
論文	Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences. Journal of pharmaceutical sciences 106 (9),2914-2918 (共著) 2017/09
論文	Arachidonic acid-containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen-induced hepatic phospholipidosis. Journal of applied toxicology : JAT 37 (8),943-953 (共著) 2017/08
論文	Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human-Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans. International journal of molecular sciences 18 (4) (共著) 2017/04
論文	Influences of long-term, high-dose acetaminophen administration on liver function markers in healthy Japanese adults Japanese Journal of Clinical Pharmacology and Therapeutics 48 (5),153-159頁 (共著) 2017
論文	A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients. Drug metabolism and pharmacokinetics 31 (6),467-470 (共著) 2016/12
論文	Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index. PloS one 11 (12),e0168188 (共著) 2016/12
論文	Plasma Lipid Profiling of Patients with Chronic Ocular Complications Caused by Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. PloS one 11 (11),e0167402 (共著) 2016/11
論文	Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations. Pharmaceutical Society of Japan, Biol Pharm Bull 39 (7),1179-86頁 (共著) 2016/07
論文	Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma. npg, Sci Rep 30 (共著) 2016/06
論文	Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats. BioMed Central, Lipids Health Dis 12 (15),74 (共著) 2016/04
論文	Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Future Medicine, Pharmacogenomics 16,1689-99頁 (共著) 2015/10
論文	Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Elsevier, Allergol Int 64,379-81頁 (共著) 2015/10
論文	Comparison of circulating lipid profiles between fasting humans and three animal species used in preclinical studies: mice, rats and rabbits. BioMed Central, Lipids Health Dis. 14,104 (共著) 2015/09
論文	Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis. npg, Sci Rep 5,12466 (共著) 2015/08
論文	IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement. Elsevier, J Allergy Clin Immunol 135 (6),1538-1545.e17頁 (共著) 2015/06
論文	Effects of sex, age, and fasting conditions on plasma lipidomic profiles of fasted Sprague-Dawley rat. Public Library of Science, PLoS One 9 (11),e112266 (共著) 2014/11
論文	Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis. Oxford Journal, Toxicol Sci 41 (2),377-86頁 (共著) 2014/10
論文	Differences in metabolite profiles between blood matrices, ages, and sexes among Caucasian individuals and their inter-individual variations. Springer, Metabolomics 10,402-13頁 (共著) 2014/06
論文	Independent strong association of HLA-A02:06 and HLA-B44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. npg, Sci Rep 4,4862 (共著) 2014/04
論文	Plasma and Serum Lipidomics of Healthy White Adults Shows Characteristic Profiles by Subjects’ Gender and Age. Public Library of Science, PLoS One 9 (共著) 2014/03
論文	Identification of a novel HLA-B allele HLA-B*07:185 in a Japanese individual. Wiley, Tissue Antigens 82,434-6頁 (共著) 2013/12
論文	Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. Future Medicine, Pharmacogenomics 14,1821-31頁 (共著) 2013/12
論文	Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. Elsevier, J Mol Cell Cardiol 59,76-85頁 (共著) 2013/10
論文	Lipidomic Analysis of Brain Tissues and Plasma in a Mouse Model Expressing Mutated Human Amyloid Precursor Protein/Tau for Alzheimer's Disease. BioMed Central, Lipids Health Dis 12,68 (共著) 2013/05
論文	Plasma and serum from nonfasting men and women differ in their lipidomic profiles. Pharmaceutical Society of Japan, Biol Pharm Bull 36 (4),682-685頁 (共著) 2013/04
論文	NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers. The Society for Free Radical Research Japan, J Clin Biochem Nutr 52 (2),133-138頁 (共著) 2013/03
論文	Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant. Springer, Immunogenetics 64 (12),869-77頁 (共著) 2012/12
論文	Quality requirements for genomic DNA preparations and storage conditions for a high-density oligonucleotide microarray. Pharmaceutical Society of Japan, Biol Pharm Bull 35 (10),1846-1848頁 (共著) 2012/10
論文	Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese. Elsevier, Drug Metab Pharmacokinet 27 (4),447-450頁 (共著) 2012/08
論文	Genetic Variation and Haplotype Structures of the Glutathione S-transferase Genes GSTA1 and GSTA2 in Japanese Colorectal Cancer Patients. Elsevier, Drug Metab. Pharmacokinet 26 (6),646-658頁 (共著) 2011/12
論文	Genetic polymorphisms and haplotypes of por, encoding cytochrome p450 oxidoreductase, in a Japanese population. Elsevier, Drug Metab Pharmacokinet 26 (1),107-116頁 (共著) 2011/02
論文	CYP3A416 and CYP3A418 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs. Drug Metab Dispos 38 (12),2100-2104頁 (共著) 2010/12
論文	Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis. Elsevier, Drug Metab Pharmacokinet 25 (6),578-587頁 (共著) 2010/12
論文	Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel. ACS, Biochemistry 49 (40),8709-8720頁 (共著) 2010/10
論文	Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients. Springer, Cancer Chemother Pharmacol 66,95-105頁 (共著) 2010/05
論文	Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0 A Resolution. ASPET, Mol Pharmacol 77 (4),529-38頁 (共著) 2010/04
論文	Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients. Elsevier, Drug Metab. Pharmacokinet 24,565-574頁 (共著) 2009/12
論文	Substrate-dependent functional alterations of seven CYP2C9 variants found in Japanese subjects. ASPET, Drug Metab Dispos 37,1895-1903頁 (共著) 2009/09
論文	Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole:ligand-induced structural response through alpha-helical repositioning. ACS, Biochemistry 48,4762-4771頁 (共著) 2009/06
論文	Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population. Elsevier, Drug Metab Pharmacokinet 24,277-281頁 (共著) 2009/06
論文	Close association of UGT1A9 IVS1+399C>T with UGT1A128, 6 or *60 haplotype and its apparent influence on SN-38 glucuronidation in Japanese. ASPET, Drug Metab. Dispos 37,272-276頁 (共著) 2009/02
論文	Functional characterization of CYP3A4.16: catalytic activities toward midazolam and carbamazepine. Taylor & Francis Group, Xenobiotica 39,140-147頁 (共著) 2009/02
論文	Genetic variations and haplotype structures of the glutathione S-transferase genes, GSTT1 and GSTM1, in a Japanese patient population. Elsevier, Drug Metab Pharmacokinet 24,118-126頁 (共著) 2009/02
論文	Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). Elsevier, Drug Metab Pharmacokinet 23,379-384頁 (共著) 2008/10
論文	Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan. npg, Hypertens Research 31,1549-1557頁 (共著) 2008/08
論文	Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 23,139-147頁 (共著) 2008/04
論文	Influence of CYP2C1918 and CYP2C1919 alleles on omeprazole 5-Methylhydroxylation: In vitro functional analysis of recombinant enzymes expressed in Saccharomyces cerevisiae. Wiley, Basic and Clinical Pharmacology and Toxicology 102,388-393頁 (共著) 2008/04
論文	Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects - SLCO1B117 is more prevalent than 15. Elsevier, Drug Metab Pharmacokinet 22,456-461頁 (共著) 2007/12
論文	Genetic variations of VDR/NR1I1 encoding vitamin D receptor in a Japanese population. Elsevier, Drug Metab Pharmacokinet 22,462-467頁 (共著) 2007/12
論文	Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences. npg, Journal of Human Genetics 52,804-819頁 (共著) 2007/09
論文	Genetic variations and haplotype structures of a transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese. Elsevier, Drug Metab Pharmacokinet 22,212-219頁 (共著) 2007/06
論文	Functional characterization of two novel CYP2C19 variants (CYP2C1918 and CYP2C1919) found in a Japanese population. Taylor & Francis Group, Xenobiotica 37,342-355頁 (共著) 2007/04
論文	Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 22,129-135頁 (共著) 2007/04
論文	Genetic polymorphisms and haplotypes of major drug metabolizing enzymes in East Asians and their comparison with other ethnic populations. Ingenta, Current PharmacoGenomics 5,49-78頁 (共著) 2007/03
論文	A combinatorial haplotype of the UDP-glucuronosyltransferase 1A1 gene (#60-#IB) increases total bilirubin concentrations in Japanese volunteers. AACC, Clinical Chemistry 53,356-358頁 (共著) 2007/02
論文	Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 22,48-60頁 (共著) 2007/02
論文	Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymerphism. American Society of Clinical Oncology, Journal of Clinical Oncology 25,32-42頁 (共著) 2007/01
論文	Novel genetic variations and haplotypes of hepatocyte nuclear factor 4α (HNF4A) found in Japanese type II diabetic patients. Drug Metab Pharmacokinet 21,337-346頁 (共著) 2006/08
論文	Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese. LWW, Pharmacogenetics Genomics 16,497-514頁 (共著) 2006/07
論文	Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1). Elsevier, Drug Metab Pharmacokinet 21,248-256頁 (共著) 2006/06
論文	Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 21,109-121頁 (共著) 2006/04
論文	Functional analysis of three CYP1A2 variants found in a Japanese population. ASPET, Drug Metab Dispos,1905-1910頁 (共著) 2005/12
論文	Genetic variations and haplotypes of CYP2C19 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 20,300-307頁 (共著) 2005/08
論文	Genetic polymorphisms and haplotypes of the human cardiac sodium channel alpha subunit gene (SCN5A) in Japanese and their association with arrhythmia. Wiley, Annals Human Genetics 69,413-428頁 (共著) 2005/07
論文	Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. Elsevier, Drug Metab Pharmacokinet 20,24-33頁 (共著) 2005/02
論文	Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population. Elsevier, Drug Metab Pharmacokinet 19,320-326頁 (共著) 2004/08
論文	Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). Elsevier, Drug Metab Pharmacokinet 19,308-312頁 (共著) 2004/08
論文	Fourteen novel single nucleotide polymorphisms in the SLC22A2 gene encoding human organic cation transporter (OCT2). Elsevier, Drug Metab Pharmacokinet 19,239-244頁 (共著) 2004/06
論文	CYP2D6-mediated mexiletine-protein adduct formation. Pharmaceutical Society of Japan, J Health Sci (Tokyo) 50,82-85頁 (共著) 2004/02
論文	Functional analysis of three genetic polymorphisms in the glucocorticoid receptor gene. ASPET, J Pharmacol Exp Ther 307,110-116頁 (共著) 2003/10
論文	Five novel single nucleotide polymorphisms in the EPHX1 gene encoding microsomal epoxide hydrolase. Elsevier, Drug Metab Pharmacokinet 18,150-153頁 (共著) 2003/04
論文	Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects. Taylor & Francis Group, Xenobiotica 33,277-287頁 (共著) 2003/03
論文	Allele-specific long range PCR/sequencing method for allelic assignment of multiple single nucleotide polymorphisms. Elsevier, J Biochem Biophys Methods 55 (1),1-9頁 (共著) 2003/01
論文	Correlation between erythrocyte aldose reductase level and human diabetic retinopathy. BMJ Publishing Group, Br. J Ophthalmol 86 (12),1363-6頁 (共著) 2003/01
論文	Kainic acid induces leukemia inhibitory factor mRNA expression in the rat brain: differences in the time course of mRNA expression between the dentate gyrus and hippocampal CA1/CA3 subfields. Elsevier, Brain Res Mol Brain Res 107 (1),39-46頁 (共著) 2002/10
論文	糖尿病性神経障害発症におけるポリオール経路の病態生理学的意義に関する研究京都大学（博士論文） (単著) 2002/09
論文	Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method. The Japanese Pharmacological Society, The Japanese Journal of Pharmacology 88,123-126頁 (共著) 2002/01
論文	Analysis of gene expression of aldose reductase and sorbitol dehydrogenase in rat Schwann cells by competitive RT-PCR method using non-homologous DNA standards. Elsevier, Brain Research Protocol 8,67-75頁 (共著) 2001/12
論文	Biochemical and morphological changes during development of sugar cataract in Otsuka Long-Evans Tokushima Fatty (OLETF) rat. Elsevier, Exp Eye Res 73,375-381頁 (共著) 2001/09
論文	Expression of aldose reductase and sorbitol dehydrogenase genes in Schwann cells isolated from rat: effects of high glucose and osmotic stress. Elsevier Mol. Brain Research 87,251-256頁 (共著) 2001/03
論文	Clinical analysis of aldose reductase for differential diagnosis of the pathogenesis of diabetic complication. Elsevier, Anal Chim Acta 365,285-292頁 (共著) 1998/06
論文	Expression of mu- and kappa-, but not delta-, opioid receptor mRNAs is enhanced in the spinal dorsal horn of the arthritic rats. Wolters Kluwer Health, Pain 64 (2),365-371頁 (共著) 1996/02
論文	Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Elsevier, Brain Res Mol Brain Res 30 (2),203-210頁 (共著) 1995/01
論文	μ、δおよびκオピオイド受容体mRNAのラット脊髄および後根神経節における発現に関する研究京都大学（修士論文） (単著) 1994/03
論文	In situ hybridization study of mu- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia. Elsevier, Neurosci Lett 168 (1-2),97-100頁 (共著) 1994/02
論文	Molecular cloning and in situ hybridization histochemistry for rat mu-opioid receptor. Elsevier, Neurosci Res 18 (4),315-322頁 (共著) 1994/01
論文	In situ hybridization study of kappa-opioid receptor mRNA in the rat brain. Elsevier, Neurosci Lett 162 (1-2),161-164頁 (共著) 1993/11
論文	Cloning and expression of a cDNA for the rat kappa-opioid receptor. Wiley, FEBS Lett 329 (3),291-295頁 (共著) 1993/08
その他	高速液体クロマトグラフィー－質量分析計（HPLC-MS/MS）を用いたゲンタマイシン硫酸塩の品質評価法の検討医薬品医療機器レギュラトリーサイエンス 50,286-294頁 (共著) 2019
その他	心筋症の脂質メタボローム解析医歯薬出版（株）, 医学のあゆみ 249,323-8頁 (共著) 2014/04
その他	薬物相互作用に関する新ガイドライン案レギュラトリーサイエンス学会, レギュラトリーサイエンス学会誌 4,249-255頁 (共著) 2014/04
その他	薬物性肝障害の遺伝的素因医歯薬出版（株）, 医学のあゆみ 248,11-18頁 (共著) 2014/01
その他	バイオマーカー探索研究とその臨床応用に向けて日本薬学会, Yakugaku Zasshi 133,1373-9頁 (共著) 2013/12
その他	市販後安全性確保に係るバイオマーカーと診断レギュラトリ―サイエンス学会, レギュラトリ―サイエンス学会誌 3,43-55頁 (共著) 2013/01
その他	日本人を対象にしたゲノム・メタボローム解析によるバイオマーカー探索技術情報協会, Pharmstage 9,1-4頁 (共著) 2012/09
その他	医薬品の応答性に関連する遺伝子多型日本血栓止血学会, 血栓止血学会誌 20,27-36頁 (共著) 2009/02
その他	ファーマコゲノミクスによる医薬品の有効性・副作用予測秀潤社, 細胞工学 26,1020-1025頁 (共著) 2007/09
その他	エルカトニン製剤の含量評価 (一財)医薬品医療機器レギュラトリーサイエンス財団, 医薬品研究 32 (7),465-471頁 (共著) 2001/07
その他	日本薬局方L-トレオニンの薄層クロマトグラフ法による純度試験 (一財)医薬品医療機器レギュラトリーサイエンス財団, 医薬品研究 29 (4),284-289頁 (共著) 1998/04