研究者データベース
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オザキ ケイイチ
OZAKI Keiichi
尾﨑 惠一
所属
同志社女子大学 薬学部 医療薬学科
職種
教授
著書・論文歴
著書
「タンパク質科学イラストレイテッド」,211-224頁 (共著) 2005/11
著書
「IRS-2をつぶすとNIDDMマウス」 (1999年1月号),60-61頁 (単著) 1999/01
著書
「生化学辞典 第３版」 (共著) 1998/11
著書
「受容体タンパク質」,323-326頁 (共著) 1991/03
論文
α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model. Clin Exp Immunol https://doi.org/10.1093/cei/uxae021 (共著) 2024/03
論文
Optimal combination of a cationic lipid with phospholipid for gene knockdown using siRNA lipoplexes in breast tumor cells and mouse lungs Mol.Med.Rep 28,180 (共著) 2023/07
論文
Preparation of liposomes co-encapsulating doxorubicin and mifepristone for treating multidrug-resistant cancer J. Drug Deliv. Sci.Tec. 85,104605 (共著) 2023/05
論文
A radiolabeled nanoparticle probe coated with hyaluronic acid via electrostatic interaction to diagnose CD44-positive tumors J. Drug Deliv. Sci.Tec. 73,103473 (共著) 2022/07
論文
In vitro and in vivo transfections using siRNA lipoplexes prepared by mixing siRNAs with a lipid-ethanol solution J. Drug Deliv. Sci.Tec. 75,103635 (共著) 2022/07
論文
Optimal combination of cationic lipid and phospholipid in cationic liposomes for in vitro and in vivo gene knockdown using siRNA lipoplexes Mol. Med. Rep. 26,253 (共著) 2022/06
論文
α2-antiplasmin positively regulates endothelial-to-mesenchymal transition and fibrosis progression in diabetic nephropathy Mol. Biol. Rep. 49,205-215頁 (共著) 2022/01/01
論文
Alpha2-antiplasmin deficiency affects depression and anxiety-like behavior and apoptosis induced by stress in mice. J. Basic Clin. Physiol. Pharmacol. 33,633-638頁 (共著) 2022/01
論文
Effects of sterol derivatives in cationic liposomes on biodistribution and gene knockdown in the lungs of mice systemically injected with siRNA lipoplexes Mol. Med. Rep. 24,598 (共著) 2021/06
論文
microRNA-30c attenuates fibrosis progression and vascular dysfunction in systemic sclerosis model mice. Mol. Biol. Rep. 48,3431-3437頁 (共著) 2021/04
論文
Effect of PEG-anchor in PEGylated siRNA lipoplexes on in vitro gene silencing effects and siRNA biodistribution in mice. Mol. Med. Rep. 22,4183-4196頁 (共著) 2020/08
論文
「新規ベーチェット病感受性遺伝子TRIM39RおよびI型IFN応答」 アレルギーの臨床 39,47-53頁 (共著) 2019/10/10
論文
ヒトγδT細胞抗腫瘍活性を用いた新規免疫細胞治療のための創薬研究 BIO Clinica 34 (9),77-81頁 (共著) 2019/09/09
論文
「Optimized combination of cationic lipids and neutral helper lipids in cationic liposomes for siRNA delivery into the lung by intravenous injection of siRNA lipoplexes」 J. Drug Deliv. Sci. Tec. 52,1042-1050頁 (共著) 2019/06
論文
「多発性硬化症等の自己免疫疾患治療薬作出のための化合物スクリーニング」 BIO Clinica, 34 (5),52-55.頁 (共著) 2019/05
論文
「Effect of cationic lipid type in folate-PEG-modified cationic liposomes on folate receptor-mediated siRNA transfection in tumor cells」 Pharmaceutics 11(4) (共著) 2019/04
論文
「Effect of cationic lipid type in PEGylated liposomes on siRNA delivery after intravenous injection of siRNA lipoplexes」 Wrld. Acd. Sci. 1,74-85頁 (共著) 2019/03
論文
「Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex」 J. Drug Target. 27,217-227頁 (共著) 2019/02
論文
「Establishment of novel cells stably secreting various human IL-18 recombinant proteins」 Curr. Pharm. Biotechnol. 20,47-55頁 (共著) 2019/02
論文
「大阪薬科大学におけるFD活動の新しい取り組み」 薬学教育 第2巻,63-67頁 (単著) 2019/01
論文
「Effect of cationic lipid type in cationic liposomes for siRNA delivery into the liver by sequential injection of chondroitin sulfate and cationic lipoplex」 J. Drug Deliv. Sci. Tec. 48,235-244頁 (共著) 2018/12
論文
「Establishment of novel reporter cells stably maintaining transcription factor-driven human secreted alkaline phosphatase expression」 Curr. Pharm. Biotechnol. 19,224-231頁 (共著) 2018/03
論文
「Evaluation of in vitro and in vivo therapeutic anti-tumor efficacy by transduction of polo-like kinase 1 and heat shock transcription factor 1 small interfering RNA」 Exp. Ther. Med. 14,4300-4306頁 (共著) 2017/11
論文
「Therapeutic effects on liver- and lung-metastasized tumors of combination therapy with protein kinase N3 small interfering RNA and doxorubicin」 Oncol. Lett. 14,5157-5166頁 (共著) 2017/11
論文
「Effect of chondroitin sulfate on siRNA biodistribution and gene silencing effect in mice after injection of siRNA lipoplexes」 J. Drug Deliv. Sci. Tec. 41,401-409頁 (共著) 2017/08
論文
「Evaluation of the injection route of an anionic polymer for small interfering RNA delivery into the liver by sequential injection of anionic polymer and cationic lipoplex of small interfering RNA」 J. Drug Deliv. Sci. Tec. 35,40-49頁 (共著) 2016/10
論文
「Therapeutic effect for liver-metastasized tumor by sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA」 J. Drug Target. 24,309-317頁 (共著) 2016/04
論文
「TNF-α induces caspase-1 activation independently of simultaneously induced NLRP3 in 3T3-L1 cells」 J. Cell Physiol. 231,2761-2767頁 (共著) 2016/03
論文
「Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes」 Am. J. Physiol. Endocrinol. Metab. 310,E643-E651頁 (共著) 2016/02
論文
「Zoledronic acid enhances antitumor efficacy of liposomal doxorubicin」 Int. J. Oncol. 47,211-219頁 (共著) 2015/04
論文
「Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human xenograft models」 Biochem. Biophys. Res. Commun. 433,456-462頁 (共著) 2013/03
論文
「Atypical protein phosphatases: emerging players in cellular signaling」 Int. J. Mol. Sci. 14,4596-4612頁 (共著) 2013/02
論文
「Targeting the extracellular signal-regulated kinase pathway in cancer therapy」 Biol. Pharm. Bull. 34,1781-1784頁 (共著) 2011/12
論文
「Blockade of the ERK or PI3K-Akt pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib」 Biochem. Biophys. Res. Commun. 391,1610-1615頁 (共著) 2010/03
論文
「Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models」 Clin. Cancer Res. 16,1170-1178頁 (共著) 2010/02
論文
「シグナル伝達病としてのメタボリックシンドロームの発症メカニズムの解明とその新規治療戦略の確立」 医科学応用研究財団研究報告 27,243-248頁 (単著) 2010/02
論文
「Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells」 Biochem. Biophys. Res. Commun. 378,650-655頁 (共著) 2009/10
論文
「細胞内シグナル伝達経路の選択的遮断を基盤としたがん治療戦略」 ファルマシア Vol.44,219-224.頁 (共著) 2008/03
論文
「Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging agents」 Cancer Sci. 99,376-384頁 (共著) 2008/02
論文
「Anticancerdrugs upregulate HspBP1 and therby antagonize the prosurvival function of Hsp70 in tumor cells」 J. Biol. Chem. 282,35430-35439頁 (共著) 2007/12
論文
「細胞内シグナル伝達経路の遮断を基盤とした新規がん分子標的治療法の開発」 薬学雑誌 127巻,983-991頁 (単著) 2007/06
論文
「Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated」 Mol. Cancer Ther. 6,1133-1142頁 (共著) 2007/03
論文
「Inhibition of PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner」 Biochem. Biophys. Res. Commun 340,560-566頁 (共著) 2006/02
論文
「Blockade of the ERK pathway markedly sensitizes tumor cells to HDAC inhibitor-induced cell death」 Biochem. Biophys. Res. Commun. 339,1171-1177頁 (共著) 2006/01
論文
「Efficient suppression of fibroblast growth factor-2 induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms」 J. Cell Sci. 118,5861-5871頁 (共著) 2005/12
論文
「Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility」 J. Biol. Chem 177,28256-28264頁 (共著) 2002/08
論文
「Blockade of the extracellular signal-regulated kinase pathway enhances the anti-tumor activity of microtubule depolymerizing agents in tumor cells in which the pathway is constitutively activated」 Proc. Am. Assoc. Cancer Res. 43,2891 (共著) 2002/04
論文
「ERK pathway positively regulates the expression of Sprouty genes」 Biochem. Biophys. Res. Commun. 285,1084-1088頁 (共著) 2001/08
論文
「Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas」 Proc. Natl. Acad. Sci. USA 96,6267-6272頁 (共著) 1999/05
論文
「Insulin receptor-related receptor (IRR) in rat islets of Langerhans」 Eur. J. Endocr. 139,244-247頁 (単著) 1998/08
論文
「Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain」 Biochem. Biophys. Res. Commun. 244,187-191頁 (共著) 1998/03
論文
「Structure and expression of a novel member, FGF-16, of the fibroblast growth factor family」 Biochem. Biophys. Res. Commun. 243,148-152頁 (共著) 1998/02
論文
「Localization of Insulin receptor-related receptor in the rat kidney」 Kidney Int. 5 52,694-698頁 (共著) 1997/09
論文
「Expression of insulin receptor-related receptor in the rat brain examined by in situ hybridization and immunohistochemistry」 Mol. Brain Res. 41,250-258頁 (共著) 1996/09
論文
「腹腔マクロファージレクチンの構造と機能に関する分子生物学的研究」 博士論文 (単著) 1995/07
論文
「Localization of fibroblast growth factor-9 mRNA in the rat brain」 Mol. Brain Res. 30,233-241頁 (共著) 1995/06
論文
「The differences in structural specificity for recognition and binding between asialoglycoprotein receptors of liver and macrophages」 Glycoconj. J. 12,268-274.頁 (共著) 1995/06
論文
Expression of insulin receptor-related receptor mRNA in the rat brain is highly restricted to forebrain cholinergic neurons Neurosci. Let. 188,105-108頁 (共著) 1995/03
論文
Insulin receptor-related receptor mRNA in the stomach is focally expressed in the enterochromaffin-like cell Endocrinology 136,558-561頁 (共著) 1995/02
論文
「Rat FGF receptor-4 mRNA in the brain is expressed preferentially in the medial habenular nucleus」 Mol. Brain Res. 21,344-348頁 (共著) 1994/02
論文
Role of tyrosine-5 in the cytoplasmic tail of the macrophage asialoglycoprotein receptor in the rapid internalization of ligands J. Biochem 113,271-276頁 (共著) 1993/03
論文
Expression of a functional asialoglycoprotein receptor through transfection of a cloned cDNA that encodes a macrophage lectin J. Biol. Chem 267,9229-9235頁 (共著) 1992/07
論文
The secretin precursor gene J. Biol. Chem. 266,12595-12598頁 (共著) 1991/07
論文
「腹腔マクロファージレクチンの機能解析」 修士論文 (単著) 1991/03
論文
「Two forms of messenger RNA encoding rat liver mannan-binding protein are generated by differential utilization of polyadenylation sites of one transcript」 J. Biochem. 108,914-917頁 (共著) 1990/12
論文
「A monoclonal antibody directed to Tn antigen」 Biochem. Biophys. Res. Commun. 170,981-985頁 (共著) 1990/08
その他
「魔法の弾丸～がん分子標的薬の可能性を追いかけて」 同志社時報 No.153,64-65頁 (単著) 2022/04/01
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