研究者データベース - 岩田　和実

イワタ　カズミ IWATA Kazumi
岩田　和実

所属同志社女子大学薬学部医療薬学科

職種特別任用教授

著書・論文歴
論文	Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase. FEBS letters 2025/03/24
論文	Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells Biomolecules 2025/01/06
論文	Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation. Scientific reports 14 (1),19288-19288頁 2024/08/20
論文	Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer? Biomolecules 13 (2) (共著) 2023/02/11
論文	Bortezomib is an effective enhancer for chemical probe-dependent superoxide detection. Frontiers in medicine 9,941180-941180頁 (共著) 2022/12
論文	Alleviative effects of glutamate against chemotherapeutic agent-induced intestinal mucositis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 73 (4) (共著) 2022/08
論文	NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis Journal of Pharmacological Sciences 146 (2),88-97頁 (共著) 2021/06
論文	NOX1/NADPH oxidase promotes synaptic facilitation induced by repeated D2 receptor stimulation; involvement in behavioral repetition. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (12),2780-2794頁 (共著) 2021/02/08
論文	NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model. Biochemical and biophysical research communications 534,59-66頁 (共著) 2021/01/01
論文	Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells. Archives of toxicology 95 (1),135-148頁 (共著) 2021/01
論文	All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds. Neuron 106 (5),816-829頁 (共著) 2020/06/03
論文	NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function. Free radical biology & medicine 147,90-101頁 (共著) 2020/02/01
論文	NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels. The FEBS journal 286 (4),678-687頁 (共著) 2019/02
論文	Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3. Neurotoxicology 67,296-304頁 (共著) 2018/07
論文	Up-regulation of NOX1/NADPH oxidase following drug-induced myocardial injury promotes cardiac dysfunction and fibrosis. Free radical biology & medicine 120,277-288頁 (共著) 2018/05/20
論文	Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein. The Journal of toxicological sciences 43 (4),257-266頁 (共著) 2018/04
論文	The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease. Free radical biology & medicine 115,412-420頁 (共著) 2018/02/01
論文	Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (15),4200-4212頁 (共著) 2017/04/12
論文	NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis. The Journal of pharmacology and experimental therapeutics 360 (1),192-200頁 (共著) 2017/01
論文	Differential roles of NOX1/NADPH oxidase derived ROS in cardiovascular disease. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 147 (1),12-7頁 (単著) 2016/01
論文	喫煙成分のアミロイドβ蛋白動態への影響家族性アルツハイマー病細胞モデルを用いた検討臨床薬理 46 (Suppl.),S231-S231頁 2015/11
論文	NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. Free radical biology & medicine 83,21-30頁 (共著) 2015/06
論文	A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia. Journal of pharmacological sciences 127 (3),370-6頁 (共著) 2015/03
論文	Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase. Free radical biology & medicine 68,196-204頁 (共著) 2014/03
論文	Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. Journal of pharmacological sciences 124 (4),427-432頁 (共著) 2014/03
論文	Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling. Arteriosclerosis, thrombosis, and vascular biology 34 (1),110-9頁 2014/01
論文	ROS are required for mouse spermatogonial stem cell self-renewal. Cell stem cell 12 (6),774-786頁 (共著) 2013/06/06
論文	NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis. Free radical biology & medicine 53 (9),1718-1728頁 (共著) 2012/11/01
論文	Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling. Toxicology 299 (1),55-59頁 (共著) 2012/09/04
論文	Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. American journal of physiology. Gastrointestinal and liver physiology 302 (10),G1133-G1142頁 (共著) 2012/05/15
論文	Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience 31 (49),18094-103頁 2011/12/07
論文	NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology (Baltimore, Md.) 54 (3),949-958頁 (共著) 2011/09/02
論文	Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene. The FEBS journal 278 (6),964-972頁 (共著) 2011/04
論文	Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation. Free radical biology & medicine 50 (6),680-688頁 (共著) 2011/03/15
論文	NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models. Journal of pharmacological sciences 111 (3),260-268頁 (共著) 2009/11
論文	The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: Possible involvement of the ERK1/2-JunB pathway. Biochemical and biophysical research communications 374 (2),351-355頁 (共著) 2008/09/19
論文	Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 (38),9486-9494頁 (共著) 2008/09/17
論文	Myocyte enhancer factor 2B is involved in the inducible expression of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme. The FEBS journal 274 (19),5128-5136頁 (共著) 2007/10
論文	The activity of aldose reductase is elevated in diabetic mouse heart. Journal of pharmacological sciences 103 (4),408-416頁 (共著) 2007/04
論文	Aldose reductase inhibitors improve myocardial reperfusion injury in mice by a dual mechanism. Journal of pharmacological sciences 102 (1),37-46頁 (共著) 2006/09
論文	NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth. Free radical biology & medicine 40 (10),1785-1795頁 (共著) 2006/05/15
論文	Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Biological & pharmaceutical bulletin 29 (5),1042-1045頁 (共著) 2006/05
論文	Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation 112 (17),2677-2685頁 (共著) 2005/10/25
論文	Effect of a Novel Non-steroidal Anti-inflammatory Drug (M-5011) on Cytokine Levels in Rats With Monosodium Urate Crystal-Induced Pleurisy Japanese Journal of Pharmacology 79 (4),439-446頁 (共著) 1999/04
論文	Antinociceptive Activity of a Novel Non-Steroidal Anti-Inflammatory Drug (M-5011) with Low Ulcerogenic Effects in Mice Japanese Journal of Pharmacology 72 (1),29-37頁 (共著) 1996/09
論文	Vasoinhibitory effect of leminoprazole, a H+,K+-atpase inhibitor, on rat aortic rings General Pharmacology: The Vascular System 27 (1),117-121頁 (共著) 1996/01
論文	Mucosal Protective Effect of Leminoprazole on Reflux Esophagitis Induced in Rats Japanese Journal of Pharmacology 69 (4),317-324頁 (共著) 1995/12
その他	The molecular mechanisms underlying NOX1/NADPH oxidase-mediated apoptosis in pulmonary arterial smooth muscle cells JOURNAL OF PHARMACOLOGICAL SCIENCES 124,105P-105P頁 2014
その他	Analysis of the role of NOX1/NADPH oxidase in renal electrolyte homeostasis JOURNAL OF PHARMACOLOGICAL SCIENCES 121,208P-208P頁 2013
その他	Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox1-deficient mice JOURNAL OF PHARMACOLOGICAL SCIENCES 115,214P-214P頁 2011
その他	The molecular mechanisms involved in NOX1/NADPH oxidase-mediated pulmonary hypertension JOURNAL OF PHARMACOLOGICAL SCIENCES 112,86P-86P頁 2010
その他	A critical role for NOX1/NADPH oxidase in the pathogenesis of pulmonary hypertension JOURNAL OF PHARMACOLOGICAL SCIENCES 109,104P-104P頁 2009
その他	NADPH oxidase implicated in the pathophysiology of cardiovascular and inflammatory diseases JOURNAL OF PHARMACOLOGICAL SCIENCES 109,20P-20P頁 2009
その他	An aldose reductase inhibitor protects myocardial ischemia-reperfusion injury in mice JOURNAL OF PHARMACOLOGICAL SCIENCES 106,219P-219P頁 2008
その他	Nox1-derived ROS enhance cardiomyocyte apoptosis and aggravate cardiac dysfunction in sepsis JOURNAL OF PHARMACOLOGICAL SCIENCES 106,68P-68P頁 2008
その他	Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Toxicology letters 170 (3),238-247頁 (共著) 2007/05/15
その他	Inhibition of aldose reductase improves myocardial reperfusion injury by a dual mechanism JOURNAL OF PHARMACOLOGICAL SCIENCES 100,86P-86P頁 2006
その他	Nox1, a catalytic subunit of NADPH oxidase mediates angiotensin II-induced hypertension JOURNAL OF PHARMACOLOGICAL SCIENCES 97,62P-62P頁 2005
その他	実験的糖尿病誘発マウスの心臓におけるアルドース還元酵素の活性化日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124,17P-18P頁 2004/11/01
その他	糖尿病合併症発症因子のクロストーク日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124,15P-16P頁 2004/11/01
その他	Up-regulation of aldose reductase by the substrate, methylglyoxal. Chemico-biological interactions 143-144,317-323頁 (共著) 2003/02/01
その他	Effects of a novel non-steroidal anti-inflammatory drug (M-5011) on bone metabolism in rats with collagen-induced arthritis EUROPEAN JOURNAL OF PHARMACOLOGY 352 (1),81-90頁 (共著) 1998/07
その他	Comparative study of the effects of indomethacin and NS-398, a selective cyclooxygenase 2 inhibitor, on duodenal bicarbonate secretion induced by luminal acidification in rats JAPANESE JOURNAL OF PHARMACOLOGY 75 (2),191-194頁 (共著) 1997/10